Evidence map›Paper›PMID 19087224›Full record

ReviewJournal of viral hepatitis2008

Primary hepatocytes as targets for hepatitis C virus replication.

M J Farquhar, J A McKeating

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of viral hepatitis, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 30 citations in OpenAlex.

  1. Current neuropharmacology · 2024
    Review
  2. Review
  3. Article
  4. Hepatitis C virus and neurological damage.World journal of hepatology · 2016
    Review
  5. Natural killer cells in hepatitis C: Current progress.World journal of gastroenterology · 2016
    Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Claudin association with CD81 defines hepatitis C virus entry.The Journal of biological chemistry · 2010
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

M J FarquharDivision of Immunity and Infection, University of Birmingham, UK.
J A McKeating
University of Birmingham · GB

Funding

Functional analysis of hepatitis C virus glycoproteinsR01AI050798 · NIAID · UNIVERSITY OF BIRMINGHAM · PI MCKEATING, JANE A. · 2004 to 2008
$1.3M
Medical Research Council G0400802Medical Research Council G0801976NIAAA NIH HHS AA140034NIAID NIH HHS AI50798NIAID NIH HHS R01 AI050798Wellcome Trust
6 · The paper itself

Abstract

Much of our current understanding of hepatitis C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent evidence suggests that lipoproteins play a key role in the HCV life cycle and virus particles derived from the sera of infected patients exist in association with host lipoproteins. This report will review the literature on HCV replication in primary hepatocytes and transformed cell lines, focusing largely on host factors defining particle entry.

Indexed as

Virus ReplicationAnimalsCell LineHepacivirusHepatitis CHepatocytesHumansReceptors, LipoproteinReceptors, VirusReceptors, LipoproteinReceptors, Virus

Identifiers

PMID19087224
PMCPMC3083516
OpenAlexW1511346493

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.