ArticleFEMS microbiology letters2009
Functional and structural characterization of chimeras of a bacterial genotoxin and human type I DNAse.
Article in FEMS microbiology letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Cytolethal distending toxin: from genotoxin to a potential biomarker and anti-tumor target.World journal of microbiology & biotechnology · 2021Review
- Microbe-Driven Genotoxicity in Gastrointestinal Carcinogenesis.International journal of molecular sciences · 2020Review
- Review
- Article
- Article
- Article
- Cytolethal distending toxin B as a cell-killing component of tumor-targeted anthrax toxin fusion proteins.Cell death & disease · 2014Article
- Cell junction remodeling in gingival tissue exposed to a microbial toxin.Journal of dental research · 2013Article
- A new functional site W115 in CdtA is critical for Aggregatibacter actinomycetemcomitans cytolethal distending toxin.PloS one · 2013Article
- Localization of Aggregatibacter actinomycetemcomitans cytolethal distending toxin subunits during intoxication of live cells.Infection and immunity · 2012Article
- Cytolethal distending toxin damages the oral epithelium of gingival explants.Journal of dental research · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Chimeras composed of the cdtB gene of a novel bacterial genotoxin and the human type I DNAse I gene were constructed and their products characterized relative to the biochemical and enzymatic properties of the native proteins. The product of a cdtB/DNAse I chimera formed a heterotrimer with the CdtA and CdtC subunits of the genotoxin, and targeted mutations increased the specific activity of the hybrid protein. Expression of active chimeric gene products established that the CdtB protein is an atypical divalent cation-dependent endonuclease and demonstrated the potential for genetically engineering a new class of therapeutic agent for inhibiting the proliferation of cancer cells.
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Registered trials
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