ArticleCanadian journal of veterinary research = Revue canadienne de recherche veterinaire2008
Markers of respiratory inflammation in horses in relation to seasonal changes in air quality in a conventional racing stable.
Article in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Biomarkers of equine asthma: A review of the current literature.Veterinary research communications · 2026Review
- Exposure to chemical pollutants and biological aerosol in indoor facilities for recreational and sport horses.BMC veterinary research · 2024Article
- Environmental Management of Equine Asthma.Animals : an open access journal from MDPI · 2024Review
- Decision Making in Severe Equine Asthma-Diagnosis and Monitoring.Animals : an open access journal from MDPI · 2023Review
- Horse Racing as a Model to Study the Relationship between Air Pollutants and Physical Performance.Animals : an open access journal from MDPI · 2022Article
- Framing Future of Work Considerations through Climate and Built Environment Assessment of Volunteer Work Practices in the United States Equine Assisted Services.International journal of environmental research and public health · 2021Article
- Managing Free-Range Laying Hens-Part B: Early Range Users Have More Pathology Findings at the End of Lay but Have a Significantly Higher Chance of Survival-An Indicative Study.Animals : an open access journal from MDPI · 2020Article
- Increased Weekly Mean PMFrontiers in veterinary science · 2020Article
- Equine Asthma: Current Understanding and Future Directions.Frontiers in veterinary science · 2020Review
- Effect of injected dexamethasone on relative cytokine mRNA expression in bronchoalveolar lavage fluid in horses with mild asthma.BMC veterinary research · 2019Article
- Garlic (Animals : an open access journal from MDPI · 2019Article
- Bronchoalveolar Lavage Cytology Characteristics and Seasonal Changes in a Herd of Pastured Teaching Horses.Frontiers in veterinary science · 2019Article
- Gene set enrichment analysis of the bronchial epithelium implicates contribution of cell cycle and tissue repair processes in equine asthma.Scientific reports · 2018Article
- Equine asthma: Integrative biologic relevance of a recently proposed nomenclature.Journal of veterinary internal medicine · 2018Review
- Diurnal rhythms of heart and respiratory rates in donkeys of different age groups during the cold-dry and hot-dry seasons in a tropical savannah.Physiological reports · 2018Article
- Reducing Respiratory Health Risks to Horses and Workers: A Comparison of Two Stall Bedding Materials.Animals : an open access journal from MDPI · 2015Article
- Installation of mechanical ventilation in a horse stable: effects on air quality and human and equine airways.Environmental health and preventive medicine · 2011Article
- Influence of horse stable environment on human airways.Journal of occupational medicine and toxicology (London, England) · 2009Article
- Inflammatory Airway Disease of Horses--Revised Consensus Statement.Journal of veterinary internal medicineArticle
- Investigating the link between particulate exposure and airway inflammation in the horse.Journal of veterinary internal medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Airborne factors in a conventionally managed racing stable and markers of pulmonary inflammation in the stabled horses were investigated on 3 occasions at 6-month intervals, including 2 winter periods and the intervening summer period. The stable measurements included inside and outside ambient temperature and relative humidity, levels of total and respirable dust, endotoxin, and 1,3-beta-glucan. Horses (n = 12) were examined in detail clinically as well as by endoscopy, bronchoalveolar lavage (BAL) cytology, and real-time polymerase chain reaction (RT-PCR) analysis of BAL-cells for IL-6 and IL-10 mRNA. Indoor measurements showed low dust levels irrespective of season. Inhalable dust, as well as 1,3-beta-glucan, were higher during the winter stabling period, whereas endotoxin levels were higher during summer. Complete data from all sampling occasions to be used for further evaluation was obtained for only 8 of the horses. There was a trend for elevation of BAL neutrophils in the horses during winter stabling that coincided with a 3.7-fold increased expression of IL-6 mRNA in BAL cells (P = 0.014). Compared to summer sampling, IL-10 mRNA expression was significantly upregulated in only 1 of the winter sampling occasions, implicating influence on immune regulation by factor/s apart from seasonal differences. Our findings suggest up-regulation of innate immunity in the airways of stabled horses; in particular involving IL-6 in association with mild elevations in respirable dust, 1,3-beta-glucan, and/or cold ambient air. However, given that this study was observational, other unmeasured environmental factors associated with winter stabling need to be considered.
Indexed as
Identifiers
19086376PMC2568048What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.