Evidence map›Paper›PMID 19086329›Full record

ArticleAlimentary pharmacology & therapeutics2008

Hepatitis C patients' self-reported adherence to treatment with pegylated interferon and ribavirin.

J J Weiss, L Bhatti, D T Dieterich, B R Edlin, D A Fishbein, M B Goetz, K Yu, G J Wagner

Abstract readMulticenter Study
In one paragraph

Article in Alimentary pharmacology & therapeutics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Trial
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  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Adherence to hepatitis C virus therapy and early virologic outcomes.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009
    Article
  14. Impact of hepatitis C treatment initiation on adherence to concomitant medications.The Journal of the Association of Nurses in AIDS Care : JANAC
    Article
  15. Self-reported treatment adherence in inflammatory bowel disease in Indian patients.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

J J WeissDepartment of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA. Jeffrey.Weiss@msnyuhealth.org
L Bhatti
D T Dieterich
B R Edlin
D A Fishbein
M B Goetz
K Yu
G J Wagner

Funding

Adherence to HCV Treatment in HCV and HCV/HIV PatientsK23MH071177 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI WEISS, JEFFREY J · 2005 to 2009
$730k
NIMH NIH HHS K23 MH071177NIMH NIH HHS K23MH071177
6 · The paper itself

Abstract

backgroundPrior research on adherence to hepatitis C treatment has documented rates of dose reductions and early treatment discontinuation, but little is known about patients' dose-taking adherence.

aimsTo assess the prevalence of missed doses of pegylated interferon and ribavirin and examine the correlates of dose-taking adherence in clinic settings.

methodsOne hundred and eighty patients on treatment for hepatitis C (23% coinfected with HIV) completed a cross-sectional survey at the site of their hepatitis C care.

resultsSeven per cent of patients reported missing at least one injection of pegylated interferon in the last 4 weeks and 21% reported missing at least one dose of ribavirin in the last 7 days. Dose-taking adherence was not associated with HCV viral load.

conclusionsSelf-reported dose non-adherence to hepatitis C treatment occurs frequently. Further studies of dose non-adherence (assessed by method other than self-report) and its relationship to HCV virological outcome are warranted.

Indexed as

HIV-1Antiviral AgentsCross-Sectional StudiesDrug Therapy, CombinationFemaleHepatitis CHIV InfectionsHumansInterferonsMaleMiddle AgedPatient ComplianceRibavirinTreatment OutcomeViral LoadAntiviral AgentsInterferonsRibavirin

Identifiers

PMID19086329
PMCPMC2891196

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.