ArticleMicrocirculation (New York, N.Y. : 1994)2008
Fluid shear attenuates endothelial pseudopodia formation into the capillary lumen.
Article in Microcirculation (New York, N.Y. : 1994), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 15 citations in OpenAlex.
- Transmission electron microscopy of transbronchial lung cryobiopsy samples in a cohort of fibrotic interstitial lung disease patients - feasibility and implications of endothelial alterations.Respiratory research · 2024Article
- Fluid forces control endothelial sprouting.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Biomechanical aspects of the auto-digestion theory.Molecular & cellular biomechanics : MCB · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
objectiveEndothelial cells have the ability to undergo morphological shape changes, including projection of cytoplasmic pseudopodia into the capillary lumen. These cytoplasmic projections significantly influence the hemodynamic resistance to blood flow. To examine mechanotransduction mechanisms, we investigated in vivo the hemodynamic conditions in capillaries that control endothelial pseudopod formation. MATERIALS AND
methodsCapillaries in rat skeletal muscle were fixed under carefully controlled perfusion conditions. The formation of endothelial pseudopodia were observed in cross-sections with electron microscopy and quantified with differential interference contrast microscopy under physiological, stasis, and reperfusion flow conditions.
resultsApplication of physiological levels of fluid flow prevents capillary endothelium to project pseudopodia into the capillary lumen. Reduction of fluid flow to near zero promotes the incidence of pseudopod projection from 5% to 55% of capillaries. After capillary pseudopodia have formed under static conditions, about one-half retract upon restoration of fluid flow. The presence of red blood cells in the capillary lumen prevents pseudopod formation.
conclusionsThe results suggest that there is a mechanism that serves to control cytoplasmic projections in capillary endothelium that is under the control of hemodynamic fluid stress. Investigation of pseudopodia growth on endothelial cells may be significant in understanding capillary obstruction in cardiovascular diseases.
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Registered trials
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