ArticleMicrocirculation (New York, N.Y. : 1994)2008
K(ATP)-mediated vasodilation is impaired in obese Zucker rats.
Article in Microcirculation (New York, N.Y. : 1994), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Microvascular function in younger adults with obesity and metabolic syndrome: role of oxidative stress.American journal of physiology. Heart and circulatory physiology · 2013Trial
- Myometrial smooth muscle KATP channel activity is attenuated in a mouse model of diet-induced obesity during pregnancy†.Biology of reproduction · 2025Article
- KMicrovascular research · 2025Article
- Fat-free mass is associated with exercise pressor responses, but not cold pressor responses, in humans: influence of maximal voluntary contraction.Frontiers in sports and active living · 2024Article
- Lymphatic Collecting Vessel: New Perspectives on Mechanisms of Contractile Regulation and Potential Lymphatic Contractile Pathways to Target in Obesity and Metabolic Diseases.Frontiers in pharmacology · 2022Review
- Regulation of capillary hemodynamics by KPhysiological reports · 2021Article
- Effect of obesity on cardiovascular responses to submaximal treadmill exercise in adult males.Journal of family medicine and primary care · 2020Article
- Neuropeptide Y1 and alpha-1 adrenergic receptor-mediated decreases in functional vasodilation in gluteus maximus microvascular networks of prediabetic mice.Physiological reports · 2018Article
- The involvement of purinergic signalling in obesity.Purinergic signalling · 2018Review
- Beneficial Pleiotropic Antidepressive Effects of Cardiovascular Disease Risk Factor Interventions in the Metabolic Syndrome.Journal of the American Heart Association · 2018Article
- Smooth Muscle Ion Channels and Regulation of Vascular Tone in Resistance Arteries and Arterioles.Comprehensive Physiology · 2017Review
- Potassium Channels in Regulation of Vascular Smooth Muscle Contraction and Growth.Advances in pharmacology (San Diego, Calif.) · 2017Review
- Impaired vascular KATP function attenuates exercise capacity in obese zucker rats.Microcirculation (New York, N.Y. : 1994) · 2013Article
- Soluble epoxide hydrolase inhibition and peroxisome proliferator activated receptor γ agonist improve vascular function and decrease renal injury in hypertensive obese rats.Experimental biology and medicine (Maywood, N.J.) · 2012Article
- Cerebral microcirculatory responses of insulin-resistant rats are preserved to physiological and pharmacological stimuli.Microcirculation (New York, N.Y. : 1994) · 2012Article
- Rapid onset vasodilatation is blunted in obese humans.Acta physiologica (Oxford, England) · 2012Article
- Daming capsule restores endothelial dysfunction induced by high-fat diet.BMC complementary and alternative medicine · 2012Article
- Blood Pressure Control at Rest and during Exercise in Obese Children and Adults.Journal of obesity · 2012Article
- Improved functional vasodilation in obese Zucker rats following exercise training.American journal of physiology. Heart and circulatory physiology · 2011Article
- Metabolic syndrome reduces the contribution of K+ channels to ischemic coronary vasodilation.American journal of physiology. Heart and circulatory physiology · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveSkeletal muscle blood flow during exercise is impaired in obesity. We tested the hypothesis that the attenuated vasodilation in skeletal muscle arterioles of obese Zucker rats (OZR) is due to altered K(ATP) channel-mediated vasodilation. MATERIALS AND
methodsK(ATP) channel function was determined in isolated skeletal muscle arterioles in response to the K(ATP) opener cromakalim (0.1-10 microM) during normal myogenic tone and alpha-adrenergic-mediated tone (0.1 microM phenylephrine). The spinotrapezius muscle was prepared and the vasodilatory responses to muscle stimulation or iloprost (0.028-2.8 microM) were observed before and after the application of the K(ATP) inhibitor, glibenclamide (10 microM). Channel subunit expression was determined by using western blot analyses.
resultsCromakalim concentration-response curves were shifted in OZR as compared to lean controls. OZR exhibited impaired functional and iloprost-induced vasodilation as compared to the lean controls. Glibenclamide inhibited the functional and iloprost-induced dilation in the lean rats with no effects in the obese a nimals. Channel subunit expression was similar in femoral arteries.
conclusionThe impaired functional vasodilation in the OZR is associated with altered K(ATP) channel sensitivity.
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