ArticleJournal of cellular physiology2009
TGF-beta promotes cell death and suppresses lactation during the second stage of mammary involution.
Article in Journal of cellular physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Molecular Regulatory Mechanisms of Mammary Gland Development: A Review.Animals : an open access journal from MDPI · 2025Review
- Periconceptional and Prenatal Exposure to Metals and Extracellular Vesicle and Particle miRNAs in Human Milk: A Pilot Study.Exposure and health · 2023Article
- Review
- Attenuated TGFB signalling in macrophages decreases susceptibility to DMBA-induced mammary cancer in mice.Breast cancer research : BCR · 2021Article
- TGF-β regulates Sca-1 expression and plasticity of pre-neoplastic mammary epithelial stem cells.Scientific reports · 2020Article
- Prognostic role of Tif1γ expression and circulating tumor cells in patients with breast cancer.Molecular medicine reports · 2019Article
- The Multifaceted Role of STAT3 in Mammary Gland Involution and Breast Cancer.International journal of molecular sciences · 2018Review
- MicroRNA roles in signalling during lactation: an insight from differential expression, time course and pathway analyses of deep sequence data.Scientific reports · 2017Article
- miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy.Genes & development · 2017Article
- Mammary Gland Involution Provides a Unique Model to Study the TGF-β Cancer Paradox.Journal of clinical medicine · 2017Review
- The crossroads of breast cancer progression: insights into the modulation of major signaling pathways.OncoTargets and therapy · 2017Review
- Endocytosis and Physiology: Insights from Disabled-2 Deficient Mice.Frontiers in cell and developmental biology · 2016Review
- Expression of Human NSAID Activated Gene 1 in Mice Leads to Altered Mammary Gland Differentiation and Impaired Lactation.PloS one · 2016Article
- TIF1γ interferes with TGFβ1/SMAD4 signaling to promote poor outcome in operable breast cancer patients.BMC cancer · 2015Article
- Hormonal regulation of the immune microenvironment in the mammary gland.Journal of mammary gland biology and neoplasia · 2014Review
- Article
- Article
- Oncogenic transformation of mammary epithelial cells by transforming growth factor beta independent of mammary stem cell regulation.Cancer cell international · 2013Article
- Differential expression of cancer associated proteins in breast milk based on age at first full term pregnancy.BMC cancer · 2012Article
- Macrophages are crucial for epithelial cell death and adipocyte repopulation during mammary gland involution.Development (Cambridge, England) · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Transforming growth factor beta (TGF-beta) ligands are known to regulate virgin mammary development and contribute to initiation of post-lactation involution. However, the role for TGF-beta during the second phase of mammary involution has not been addressed. Previously, we have used an MMTV-Cre transgene to delete exon 2 from the Tgfbr2 gene in mammary epithelium, however we observed a gradual loss of T beta RII deficient epithelial cells that precluded an accurate study of the role for TGF-beta signaling during involution timepoints. Therefore, in order to determine the role for TGF-beta during the second phase of mammary involution we have now targeted T beta RII ablation within mammary epithelium using the WAP-Cre transgene [T beta RII(WKO)Rosa26R]. Our results demonstrated that TGF-beta regulates commitment to cell death during the second phase of mammary involution. Importantly, at day 3 of mammary involution the Na-Pi type IIb co-transporter (Npt2b), a selective marker for active lactation in luminal lobular alveolar epithelium, was completely silenced in the WAP-Cre control and T beta RII(WKO)Rosa26R tissues. However, by day 7 of involution the T beta RII(WKO)Rosa26R tissues had distended lobular alveoli and regained a robust Npt2b signal that was detected at the apical luminal surface. The Npt2b abundance and localization positively correlated with elevated WAP mRNA expression, suggesting that the distended alveoli were the result of an active lactation program rather than residual milk protein and lipid accumulation. In summary, the results suggest that an epithelial cell response to TGF-beta signaling regulates commitment to cell death and suppression of lactation during the second phase of mammary involution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.