ArticleCurrent eye research2008
Glucose and TGFbeta2 modulate the viability of cultured human retinal pericytes and their VEGF release.
Article in Current eye research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 22 citations in OpenAlex.
- TGF-β Signaling Pathways in the Development of Diabetic Retinopathy.International journal of molecular sciences · 2024Review
- Progression of Diabetic Capillary Occlusion: A Model.PLoS computational biology · 2016Article
- High Glucose and Glucose Deprivation Modulate Müller Cell Viability and VEGF Secretion.International journal of ophthalmology & eye science · 2016Article
- Effect of Glucose on Retinal Endothelial Cell Viability and VEGF Secretion.HSOA journal of cell biology & cell metabolism · 2016Article
- O-GlcNAc modification of transcription factor Sp1 mediates hyperglycemia-induced VEGF-A upregulation in retinal cells.Investigative ophthalmology & visual science · 2014Article
- Article
- Role of the retinal vascular endothelial cell in ocular disease.Progress in retinal and eye research · 2013Review
- Retinal not systemic oxidative and inflammatory stress correlated with VEGF expression in rodent models of insulin resistance and diabetes.Investigative ophthalmology & visual science · 2012Article
- NBHA reduces acrolein-induced changes in ARPE-19 cells: possible involvement of TGFβ.Current eye research · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeDetermine the effects of glucose and exogenous TGFbeta2 on viability and VEGF release by human retinal pericytes (HRP).
methodsHuman retinal pericytes (HRP) were cultured in 5 mM (physiologic) or high (18 mM) glucose with or without added TGFbeta2. Viable cells were counted; TGFbeta2 and VEGF in the conditioned media (CM) were measured by ELISA.
resultsHigh glucose significantly reduced viable cell number and increased the levels of TGFbeta2 and VEGF. TGFbeta2 caused a significant dose-dependent effect on viable cell number and on the level of VEGF secreted into the CM by HRP in physiologic glucose, decreasing viable cell number, and increasing VEGF release per 1000 cells at a low concentration (0.1 ng/ml) and increasing viable cell number and decreasing VEGF release per 1000 cells at higher concentrations (1.0 and 10 ng/ml). TGFbeta2 affected neither parameter in high glucose.
conclusionsElevated glucose decreased HRP viability and modulated changes in TGFbeta2 and VEGF release. This suggests a novel mechanism for HRP dropout in diabetic retinopathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.