ArticleThe Journal of experimental medicine1991
Antibodies that are specific for a single amino acid interchange in a protein epitope use structurally distinct variable regions.
Article in The Journal of experimental medicine, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
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- Principles ofbioRxiv : the preprint server for biology · 2026Article
- Monoclonal Antibodies Against Myeloid Leukemia Cells: Current Knowledge and Future Directions.International journal of molecular sciences · 2025Review
- Cancer therapy with antibodies.Nature reviews. Cancer · 2024Review
- Plasticity of Amino Acid Residue 145 Near the Receptor Binding Site of H3 Swine Influenza A Viruses and Its Impact on Receptor Binding and Antibody Recognition.Journal of virology · 2019Article
- Mechanisms, manifestations, and failures of self-tolerance.Immunologic research · 2003Review
- Virus-induced maturation and activation of autoreactive memory B cells.The Journal of experimental medicine · 2000Article
- B-cell responses to a peptide epitope: mutations in heavy chain alone lead to maturation of antibody responses.Immunology · 1999Article
- A recombinant Fab neutralizes dengue virus in vitro.Journal of biotechnology · 1999Article
- Immune recognition of influenza hemagglutinin as a viral and a neo-self-antigen.Immunologic research · 1998Review
- Self-reactive B cells in nonautoimmune and autoimmune mice.Immunologic research · 1998Review
- Regulation of anti-double-stranded DNA B cells in nonautoimmune mice: localization to the T-B interface of the splenic follicle.The Journal of experimental medicine · 1997Article
- Activation and negative selection of functionally distinct subsets of antibody-secreting cells by influenza hemagglutinin as a viral and a neo-self antigen.The Journal of experimental medicine · 1996Article
- Transgenic mice that express different forms of the influenza virus hemagglutinin as a neo-self-antigen.Journal of clinical immunology · 1995Article
- Selection of a single amino acid substitution in the hemagglutinin molecule by chicken eggs can render influenza A virus (H3) candidate vaccine ineffective.Journal of virology · 1995Article
- Specificity and VH sequence of two monoclonal antibodies against the N-terminus of dystrophin.The Biochemical journal · 1995Article
- Analysis of idiotope structure of ovarian cancer antibodies: recognition of the same epitope by two monoclonal antibodies differing mainly in their heavy chain variable sequences.Clinical and experimental immunology · 1994Article
- Human rheumatoid factors with restrictive specificity for rabbit immunoglobulin G: auto- and multi-reactivity, diverse VH gene segment usage and preferential usage of V lambda IIIb.The Journal of experimental medicine · 1994Article
- Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinations.The Journal of experimental medicine · 1993Article
- Monoclonal antibody epitopes of mycobacterial 65-kD heat-shock protein defined by epitope scanning.Clinical and experimental immunology · 1992Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have analyzed how the immune system generates antibodies that are specific for analogues of an epitope on the influenza virus hemagglutinin (HA) that differ solely by the presence of Asp or Gly at amino acid 225. Most antibodies induced in response to HA(Asp225) use one of a few closely related variable (V) region structures that are encoded by characteristic VH/Vk gene segment combinations. Remarkably, none of these VH/Vk combinations was induced in response to HA(Gly225). Instead of modifying the HA(Asp225)-specific V regions by junctional variation or somatic mutation to recognize the altered epitope, new VH/Vk combinations were used. The expression of unique VH/Vk combinations appears to confer exquisite specificity to the selection of HA-specific B cells from the pre-immune repertoire.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.