ArticlePflugers Archiv : European journal of physiology2009
Potassium currents induced by hydrostatic pressure modulate membrane potential and transmitter release in vestibular type II hair cells.
Article in Pflugers Archiv : European journal of physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 10 citations in OpenAlex.
- A synaptic F-actin network controls otoferlin-dependent exocytosis in auditory inner hair cells.eLife · 2015Article
- Article
- Enhanced vestibulo-ocular reflex to electrical vestibular stimulation in Meniere's disease.Journal of the Association for Research in Otolaryngology : JARO · 2013Article
- Pharmacological modulation of transmitter release by inhibition of pressure-dependent potassium currents in vestibular hair cells.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vestibular type II hair cells respond to increases in the hydrostatic pressure with pressure-dependent K(+) currents. We examined whether such currents may modulate transmitter release (assessed as membrane capacitance increments) by altering membrane potentials and voltage-gated Ca(2+) currents. Capacitance increments were dependent on voltage-gated Ca(2+) influx. Stimulating currents (0.7 nA) in current clamp induced depolarisations that were more negative by 8.7 +/- 2.1 mV when the bath height was elevated from 0.2 to 0.5 cm. In voltage clamp, protocols were used that simulated the time course of the membrane potential in current clamp at either low (control) or high hydrostatic pressure (high bath). The low bath protocol induced significantly larger Ca(2+) currents and increases in capacitance than the high bath protocol. We conclude that pressure-dependent K(+) currents may alter the voltage response of vestibular hair cells to an extent critical for Ca(2+) currents and transmitter release. This mechanism may contribute to vestibular dysfunction in Meniere's disease.
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