ArticleSynapse (New York, N.Y.)2009
Phosphorylation of GluR1, ERK, and CREB during spontaneous withdrawal from chronic heroin self-administration.
Article in Synapse (New York, N.Y.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Oxycodone withdrawal is associated with increased cocaine self-administration and aberrant accumbens glutamate plasticity in rats.Neuropharmacology · 2024Article
- Neuroplasticity of the extended amygdala in opioid withdrawal and prolonged opioid abstinence.Frontiers in pharmacology · 2023Review
- Activation of Trace Amine-Associated Receptor 1 Stimulates an Antiapoptotic Signal Cascade via Extracellular Signal-Regulated Kinase 1/2.Molecular pharmacology · 2019Article
- Relevance of ERK1/2 Post-retrieval Participation on Memory Processes: Insights in Their Particular Role on Reconsolidation and Persistence of Memories.Frontiers in molecular neuroscience · 2019Review
- From Synapse to Function: A Perspective on the Role of Neuroproteomics in Elucidating Mechanisms of Drug Addiction.Proteomes · 2018Review
- Src-dependent phosphorylation of μ-opioid receptor at TyrEMBO molecular medicine · 2017Article
- Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Review
- Opiate Exposure State Controls a D2-CaMKIIα-Dependent Memory Switch in the Amygdala-Prefrontal Cortical Circuit.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- The affective dimension of pain as a risk factor for drug and alcohol addiction.Alcohol (Fayetteville, N.Y.) · 2015Article
- Phosphorylation of the N-methyl-d-aspartate receptor is increased in the nucleus accumbens during both acute and extended morphine withdrawal.The Journal of pharmacology and experimental therapeutics · 2015Article
- Chronic CRF1 receptor blockade reduces heroin intake escalation and dependence-induced hyperalgesia.Addiction biology · 2015Article
- In vivo and in vitro attenuation of naloxone-precipitated experimental opioid withdrawal syndrome by insulin and selective KATP channel modulator.Psychopharmacology · 2015Article
- Drug withdrawal conceptualized as a stressor.Behavioural pharmacology · 2014Review
- Neuronal extracellular signal-regulated kinase (ERK) activity as marker and mediator of alcohol and opioid dependence.Frontiers in integrative neuroscience · 2014Review
- Acute morphine associated alterations in the subcellular location of the AMPA-GluR1 receptor subunit in dendrites of neurons in the mouse central nucleus of the amygdala: comparisons and contrasts with other glutamate receptor subunits.Synapse (New York, N.Y.) · 2013Article
- Corticotropin-releasing factor (CRF) and α 2 adrenergic receptors mediate heroin withdrawal-potentiated startle in rats.The international journal of neuropsychopharmacology · 2013Article
- Central amygdala GluA1 facilitates associative learning of opioid reward.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Modulation of histone deacetylase attenuates naloxone-precipitated opioid withdrawal syndrome.Naunyn-Schmiedeberg's archives of pharmacology · 2012Article
- Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: alleviation by CRF₁ receptor antagonism.Neuropharmacology · 2012Article
- Evidence that vasopressin V1b receptors mediate the transition to excessive drinking in ethanol-dependent rats.Addiction biology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Negative motivational symptoms are observed soon after withdrawal from chronic opiate administration, and are thought to mediate dependence. Examination of brain region-specific signaling changes that accompany early withdrawal may shed light on neural mechanisms underlying negative reinforcement and dependence. Thus, we measured alterations in protein phosphorylation in multiple limbic brain regions in rats undergoing 24 h spontaneous or naltrexone-precipitated withdrawal from chronic (6 h/day) i.v. heroin self-administration. Region-specific increases in cyclic AMP-dependent GluR(1) (S845) phosphorylation were found in the nucleus accumbens shell, basolateral amygdala, hippocampal CA1 and CA3 subregions, and premotor cortex from 12 to 24 h of spontaneous withdrawal, and there were no changes in prefrontal cortex, nucleus accumbens core or caudate-putamen. Increased GluR(1) (S845) phosphorylation was detected earlier (12 h withdrawal) in the central amygdala and ventral tegmental area. In contrast, prominent increases in extracellular signal-regulated kinase phosphorylation were found in both prefrontal and premotor cortex, and CA1 and CA3 between 12 and 24 h withdrawal. Phosphorylation of striatal cyclic AMP response element binding protein increased in the caudate-putamen but not in the nucleus accumbens. Naltrexone administration after 24 h withdrawal increased extracellular signal-regulated kinase phosphorylation in the central amygdala, and nucleus accumbens core and shell. Thus, spontaneous withdrawal from heroin self-administration produces region- and time-dependent changes in cyclic AMP and extracellular signal-regulated kinase activity that could contribute to the behavioral manifestation of opiate dependence.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.