ArticleThe Journal of hand surgery2008
Effect of interleukin-10 overexpression on the properties of healing tendon in a murine patellar tendon model.
Article in The Journal of hand surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Article
- Exosome Cell Origin AffectsTissue engineering. Part A · 2023Article
- Advanced Gene Therapy Strategies for the Repair of ACL Injuries.International journal of molecular sciences · 2022Review
- New frontiers of tendon augmentation technology in tissue engineering and regenerative medicine: a concise literature review.The Journal of international medical research · 2022Review
- Engineering Musculoskeletal Grafts for Multi-Tissue Unit Repair: Lessons From Developmental Biology and Wound Healing.Frontiers in physiology · 2021Review
- Potential Mechanisms of the Impact of Hepatocyte Growth Factor Gene-Modified Tendon Stem Cells on Tendon Healing.Frontiers in cell and developmental biology · 2021Article
- Plasma Concentrations of Select Inflammatory Cytokines Predicts Pain Intensity 48 Hours Post-Shoulder Muscle Injury.The Clinical journal of pain · 2020Article
- Therapeutic Efficacy of Intratendinous Delivery of Dexamethasone Using Porous Microspheres for Amelioration of Inflammation and Tendon Degeneration on Achilles Tendinitis in Rats.BioMed research international · 2020Article
- Wound-healing effects of 635-nm low-level laser therapy on primary human vocal fold epithelial cells: an in vitro study.Lasers in medical science · 2019Article
- Interleukin‑10 promotes proliferation and migration, and inhibits tendon differentiation via the JAK/Stat3 pathway in tendon‑derived stem cells in vitro.Molecular medicine reports · 2018Article
- The roles of inflammatory mediators and immunocytes in tendinopathy.Journal of orthopaedic translation · 2018Review
- Exploring the In Vivo Anti-Inflammatory Actions of Simvastatin-Loaded Porous Microspheres on Inflamed Tenocytes in a Collagenase-Induced Animal Model of Achilles Tendinitis.International journal of molecular sciences · 2018Article
- Uncovering the effect of low-frequency static magnetic field on tendon-derived cells: from mechanosensing to tenogenesis.Scientific reports · 2017Article
- Photobiomodulation therapy on collagen type I and III, vascular endothelial growth factor, and metalloproteinase in experimentally induced tendinopathy in aged rats.Lasers in medical science · 2016Article
- Co-transfection of decorin and interleukin-10 modulates pro-fibrotic extracellular matrix gene expression in human tenocyte culture.Scientific reports · 2016Article
- In vitro functional response of human tendon cells to different dosages of low-frequency pulsed electromagnetic field.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Article
- The low level laser therapy (LLLT) operating in 660 nm reduce gene expression of inflammatory mediators in the experimental model of collagenase-induced rat tendinitis.Lasers in medical science · 2015Article
- Gene therapy approaches to regenerating the musculoskeletal system.Nature reviews. Rheumatology · 2015Review
- Biologics for tendon repair.Advanced drug delivery reviews · 2015Review
- Regenerative Wound Healing: The Role of Interleukin-10.Advances in wound care · 2014Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
purposeInterleukin-10 (IL-10) is a potent anti-inflammatory cytokine shown to inhibit scar formation in fetal wound healing. The role of IL-10 in adult tendon healing and scar formation, however, remains unknown. The objective of this study is to investigate the effect of IL-10 overexpression on the properties of adult healing tendon using a well-established murine model of tendon injury and a lentiviral-mediated method of IL-10 overexpression.
methodsA murine model of patellar tendon injury was used and animals divided into 3 groups. Mice received bilateral patellar tendon injections with a lentiviral vector containing an IL-10 transgene (n = 34) or no transgene (n = 34). Control mice (n = 34) received injections of sterile saline. All animals then were subjected to bilateral, central patellar tendon injuries 2 days after injection and were killed at 5, 10, 21, and 42 days after injury. IL-10 content was analyzed by immunohistochemistry (n = 4/group). Tendon healing was evaluated by histology (n = 4/group) and biomechanical analysis (n = 10/group).
resultsOverexpression of IL-10 in patellar tendon was confirmed after injection of the lentiviral vector. IL-10 immunostaining was increased at day 10 in the IL-10 group relative to that in controls. Histologically, there was no significant difference in angular deviation between groups at day 21, but a trend toward decreased angular deviation in controls relative to that in empty vector group mice was seen at day 42. Biomechanically, the IL-10 group showed significantly increased maximum stress at day 42 relative to that in controls. Percent relaxation showed a trend toward an increase at day 10 and a significant increase at day 42 in the IL-10 group relative to that in controls.
conclusionsThis study demonstrates successful gene transfer of IL-10 into adult murine patellar tendon using a lentiviral vector. Although the effects of overexpression of IL-10 on adult tendon healing have not yet been fully elucidated, the current study may help to further clarify the mechanisms of tendon injury and repair.
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