ReviewJournal of theoretical biology2009
Scaling aspects of lymphocyte trafficking.
Review in Journal of theoretical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Regulatory T cell therapies: biological foundations, engineering strategies, and clinical translation.Frontiers in immunology · 2026Review
- Multiscale physiologically-based model of age-dependent CD4+ T-lymphocyte homeostasis.Frontiers in immunology · 2026Article
- Bigger is faster in the adaptive immune response.Scientific reports · 2025Article
- Radiation-Induced Lymphopenia: In Silico Replications of Preclinical Studies Suggest Importance of Dose to Lymphoid Organs.International journal of radiation oncology, biology, physics · 2025Article
- Transport Barriers Influence the Activation of Anti-Tumor Immunity: A Systems Biology Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 2: Model for the Drug-combination Nanoparticles.Journal of pharmaceutical sciences · 2022Article
- Predicted limited redistribution of T cells to secondary lymphoid tissue correlates with increased risk of haematological malignancies in asplenic patients.Scientific reports · 2021Article
- The impacts of body mass on immune cell concentrations in birds.Proceedings. Biological sciences · 2020Article
- Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans.Frontiers in physiology · 2020Article
- The relationship of mammal survivorship and body mass modeled by metabolic and vitality theories.Population ecology · 2018Article
- Clinical Grade Regulatory CD4Frontiers in immunology · 2018Review
- Of mice, macaques and men: scaling of virus dynamics and immune responses.Frontiers in microbiology · 2015Article
- Spatial modeling of HIV cryptic viremia and 2-LTR formation during raltegravir intensification.Journal of theoretical biology · 2014Article
- Estimating the diversity, completeness, and cross-reactivity of the T cell repertoire.Frontiers in immunology · 2013Review
- Regulatory T-cell therapy in transplantation: moving to the clinic.Cold Spring Harbor perspectives in medicine · 2013Review
- Quantifying T lymphocyte turnover.Journal of theoretical biology · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
We consider the long lived pool of B and T cells that recirculate through blood, tissues and the lymphatic system of an animal with body mass M. We derive scaling rules (allometric relations) for: (1) the rate of production of mature lymphocytes, (2) the accumulation of lymphocytes in the tissues, (3) the flux of lymphocytes through the lymphatic system, (4) the number of lymph nodes, (5) the number of lymphocytes per clone within a lymph node, and (6) the total number of lymphocytes within a lymph node. Mass-dependent aspects of immune learning and of the immunological self are shown to be not very significant. Our treatment is somewhat heuristic and aims at combining immunological data with recent progress in biological scaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.