ReviewBiogerontology2009
Roles of RECQ helicases in recombination based DNA repair, genomic stability and aging.
Review in Biogerontology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 91 citations in OpenAlex.
- Identification of VVD-214/RO7589831, a Clinical-Stage, Covalent Allosteric Inhibitor of WRN Helicase for the Treatment of MSI-High Cancers.Journal of medicinal chemistry · 2025Article
- Comparative Genomics Reveal Distinct Environment Preference and Functional Adaptation Among Lineages of Gemmatimonadota.Microorganisms · 2024Article
- Article
- R-Loops in Genome Instability and Cancer.Cancers · 2023Review
- Clinical prospects of WRN inhibition as a treatment for MSI tumours.NPJ precision oncology · 2022Review
- shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination.Chromosoma · 2020Article
- Article
- Article
- Overexpression of RECQL4 is associated with poor prognosis in patients with gastric cancer.Oncology letters · 2018Article
- Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence.Cell death & disease · 2018Article
- Lymphangioleiomyomatosis: a case report and review of diagnosis and treatment.OncoTargets and therapy · 2018Article
- Loss of p21 promoted tumorigenesis in the background of telomere dysfunctions induced by TRF2 and Wrn deficiency.International journal of biological sciences · 2018Article
- Molecular-genetic profiling and high-throughputOncotarget · 2017Article
- A Comparative Study of G-Quadruplex Unfolding and DNA Reeling Activities of Human RECQ5 Helicase.Biophysical journal · 2016Article
- Phenotypes and genotypes of the chromosomal instability syndromes.Translational pediatrics · 2016Review
- Manipulation of DNA Repair Proficiency in Mouse Models of Colorectal Cancer.BioMed research international · 2016Review
- Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand.The Journal of biological chemistry · 2015Article
- Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.Oncogene · 2015Article
- WRN protein as a novel erythroblast immunohistochemical marker with applications for the diagnosis of Werner syndrome.Virchows Archiv : an international journal of pathology · 2015Article
- Epigenetic Regulation of Werner Syndrome Gene in Age-Related Cataract.Journal of ophthalmology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The maintenance of the stability of genetic material is an essential feature of every living organism. Organisms across all kingdoms have evolved diverse and highly efficient repair mechanisms to protect the genome from deleterious consequences of various genotoxic factors that might tend to destabilize the integrity of the genome in each generation. One such group of proteins that is actively involved in genome surveillance is the RecQ helicase family. These proteins are highly conserved DNA helicases, which have diverse roles in multiple DNA metabolic processes such as DNA replication, recombination and DNA repair. In humans, five RecQ helicases have been identified and three of them namely, WRN, BLM and RecQL4 have been linked to genetic diseases characterized by genome instability, premature aging and cancer predisposition. This helicase family plays important roles in various DNA repair pathways including protecting the genome from illegitimate recombination during chromosome segregation in mitosis and assuring genome stability. This review mainly focuses on various roles of human RecQ helicases in the process of recombination-based DNA repair to maintain genome stability and physiological consequences of their defects in the development of cancer and premature aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.