ArticleJournal of inherited metabolic disease2009
A data-mining approach to rank candidate protein-binding partners-The case of biogenesis of lysosome-related organelles complex-1 (BLOC-1).
Article in Journal of inherited metabolic disease, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Neurodevelopmental disease mechanisms, primary cilia, and endosomes converge on the BLOC-1 and BORC complexes.Developmental neurobiology · 2018Review
- Differential Gene Expression and Protein Phosphorylation as Factors Regulating the State of the Arabidopsis SNX1 Protein Complexes in Response to Environmental Stimuli.Frontiers in plant science · 2016Article
- The BLOC-1 complex promotes endosomal maturation by recruiting the Rab5 GTPase-activating protein Msb3.The Journal of cell biology · 2013Article
- Article
- The BLOS1-interacting protein KXD1 is involved in the biogenesis of lysosome-related organelles.Traffic (Copenhagen, Denmark) · 2012Article
- Modeling disease mutations by gene targeting in one-cell mouse embryos.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Mechanisms of protein delivery to melanosomes in pigment cells.Physiology (Bethesda, Md.) · 2012Review
- Assembly and architecture of biogenesis of lysosome-related organelles complex-1 (BLOC-1).The Journal of biological chemistry · 2012Article
- Cell biology of the BLOC-1 complex subunit dysbindin, a schizophrenia susceptibility gene.Molecular neurobiology · 2011Review
- Dysbindin-containing complexes and their proposed functions in brain: from zero to (too) many in a decade.ASN neuro · 2011Review
- Yeast homologues of three BLOC-1 subunits highlight KxDL proteins as conserved interactors of BLOC-1.Traffic (Copenhagen, Denmark) · 2011Article
- Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency.Human molecular genetics · 2010Article
- The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins and role in neurite outgrowth.Molecular psychiatry · 2010Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The study of protein-protein interactions is a powerful approach to uncovering the molecular function of gene products associated with human disease. Protein-protein interaction data are accumulating at an unprecedented pace owing to interactomics projects, although it has been recognized that a significant fraction of these data likely represents false positives. During our studies of biogenesis of lysosome-related organelles complex-1 (BLOC-1), a protein complex involved in protein trafficking and containing the products of genes mutated in Hermansky-Pudlak syndrome, we faced the problem of having too many candidate binding partners to pursue experimentally. In this work, we have explored ways of efficiently gathering high-quality information about candidate binding partners and presenting the information in a visually friendly manner. We applied the approach to rank 70 candidate binding partners of human BLOC-1 and 102 candidates of its counterpart from Drosophila melanogaster. The top candidate for human BLOC-1 was the small GTPase encoded by the RAB11A gene, which is a paralogue of the Rab38 and Rab32 proteins in mammals and the lightoid gene product in flies. Interestingly, genetic analyses in D. melanogaster uncovered a synthetic sick/lethal interaction between Rab11 and lightoid. The data-mining approach described herein can be customized to study candidate binding partners for other proteins or possibly candidates derived from other types of 'omics' data.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.