ArticleMammalian genome : official journal of the International Mammalian Genome Society2009
Genetic analysis of the psychostimulant effects of nicotine in chromosome substitution strains and F2 crosses derived from A/J and C57BL/6J progenitors.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 10 citations in OpenAlex.
- Identification of candidate genes for nicotine withdrawal in C57BL/6J × DBA/2J recombinant inbred mice.Genes, brain, and behavior · 2023Article
- Inbred mouse strain differences in alcohol and nicotine addiction-related phenotypes from adolescence to adulthood.Pharmacology, biochemistry, and behavior · 2022Review
- Genetic Modifiers of Oral Nicotine Consumption inFrontiers in psychiatry · 2021Article
- C57BL/6 Substrain Differences in Pharmacological Effects after Acute and Repeated Nicotine Administration.Brain sciences · 2019Article
- GeneWeaver: finding consilience in heterogeneous cross-species functional genomics data.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Natural genetic variability of the neuronal nicotinic acetylcholine receptor subunit genes in mice: Consequences and confounds.Neuropharmacology · 2015Review
- Contrasting genetic architectures in different mouse reference populations used for studying complex traits.Genome research · 2015Review
- Do initial responses to drugs predict future use or abuse?Neuroscience and biobehavioral reviews · 2012Review
- Strain-dependent effects of acute, chronic, and withdrawal from chronic nicotine on fear conditioning.Behavior genetics · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous research utilizing the AcB/BcA recombinant congenic strains (RCS) of mice mapped provisional quantitative trait loci (QTLs) for the psychostimulant effects of nicotine to multiple regions on chromosomes 7, 11, 12, 14, 16, and 17. The current study was designed to confirm these QTLs in an A/J (A) x C57Bl/6J (B6) F2 cross and a panel of B6.A chromosome substitution strains (CSS). The panel of B6.A CSS consists of 21 strains, each carrying a different A/J chromosome on a B6 background. The A x B6 F2, CSS, A, and B6 mice were tested for sensitivity to the effects of nicotine on locomotor activity using a computerized open-field apparatus. In A x B6 F2 mice two QTLs were identified which confirm those previously observed in the AcB/BcA RCS. Significant differences in the expression of nicotine-induced activity were associated with loci on chromosome 11 (D11Mit62) and chromosome 16 (D16Mit131) in the A x B6 F2. At the chromosome 11 QTL, an A allele was associated with lower nicotine-induced activity scores relative to the B6. In contrast, the A allele was associated with greater relative nicotine activity values for the chromosome 16 QTL. A survey of the CSS panel confirmed the presence of QTLs for nicotine activation on chromosomes 2, 14, 16, and 17 previously identified in the AcB/BcA RCS. In the informative CSS strains, A alleles were consistently associated with greater nicotine-induced activity scores compared to the B6. The results of the present study are the first to validate QTLs for sensitivity to the effects of nicotine across multiple strains of mice. QTLs on chromosomes 2, 11, 14, 16, and 17 were confirmed in CSS and/or F2 mice. Significantly, the identification of a QTL on chromosome 16 has now been replicated in three crosses derived from the A and B6 progenitors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.