ArticleDigestive diseases and sciences2009
Modafinil in the treatment of debilitating fatigue in primary biliary cirrhosis: a clinical experience.
Article in Digestive diseases and sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Treatment of Fatigue in Primary Biliary Cholangitis: A Systematic Review and Meta-Analysis.Digestive diseases and sciences · 2019Pooled it
- The feasibility and acceptability of an online mind-body wellness program for patients with primary biliary cholangitis.Canadian liver journal · 2023Article
- Fatigue in chronic liver disease patients: prevalence, pathophysiology, and management.Przeglad gastroenterologiczny · 2022Review
- Diagnosis and treatment of primary biliary cholangitis.United European gastroenterology journal · 2020Review
- Sleep disturbances in patients with liver cirrhosis: prevalence, impact, and management challenges.Nature and science of sleep · 2018Review
- [Consensus on the diagnosis and management of primary biliary cirrhosis (cholangitis)].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2016Article
- Proposed therapies in primary biliary cholangitis.Expert review of gastroenterology & hepatology · 2016Review
- Managing Sleep Disturbances in Cirrhosis.Scientifica · 2016Review
- Primary biliary cirrhosis: Pathophysiology, clinical presentation and therapy.World journal of hepatology · 2015Review
- Natural history and management of primary biliary cirrhosis.Hepatic medicine : evidence and research · 2012Review
- Fatigue in primary biliary cirrhosis.Nature reviews. Gastroenterology & hepatology · 2010Review
- Latest and emerging therapies for primary biliary cirrhosis and primary sclerosing cholangitis.Current gastroenterology reports · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modafinil may be a potentially effective treatment for primary biliary cirrhosis (PBC)-related fatigue. About 42 patients were given a 3-day trial of 100-200 mg modafinil. Response was defined as increased energy, decreased somnolence and sleep requirements, and improved daily function. Patients with positive responses were continued indefinitely on the medication. During the initial trial period, 31 (73%) patients had complete response and continued to take the medication. Eleven (26%) had no response. In long-term follow-up (average 17.7 months), 25 (81%) patients continued to take 100-200 mg modafinil daily. Some required an increased dosage and some took the medication as needed. Four (12%) patients stopped the medication because of side-effects or reduced efficacy; one patient (3%) stopped due to medication cost and one (3%) due to resolution of fatigue. Side-effects included insomnia, nausea, nervousness, and headaches. Modafinil appears to be a safe, effective treatment for PBC-related fatigue.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.