ArticleMammalian genome : official journal of the International Mammalian Genome Society2009
Phenotypic integration of skeletal traits during growth buffers genetic variants affecting the slenderness of femora in inbred mouse strains.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 40 citations in OpenAlex.
- Effects of long-term voluntary wheel running and selective breeding for wheel running on femoral nutrient canals.Journal of anatomy · 2024Article
- Lifelong Excess in GH Elicits Sexually Dimorphic Effects on Skeletal Morphology and Bone Mechanical Properties.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Components of the Gut Microbiome That Influence Bone Tissue-Level Strength.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021Article
- Articular Cartilage Friction, Strain, and Viability Under Physiological to Pathological Benchtop Sliding Conditions.Cellular and molecular bioengineering · 2021Article
- External Bone Size Is a Key Determinant of Strength-Decline Trajectories of Aging Male Radii.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Dissecting the Genetics of Osteoporosis using Systems Approaches.Trends in genetics : TIG · 2019Review
- Ontogeny of hallucal metatarsal rigidity and shape in the rhesus monkey (Macaca mulatta) and chimpanzee (Pan troglodytes).Journal of anatomy · 2018Article
- Femoral Neck External Size but not aBMD Predicts Structural and Mass Changes for Women Transitioning Through Menopause.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- Canalization Leads to Similar Whole Bone Mechanical Function at Maturity in Two Inbred Strains of Mice.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2017Article
- The development of inter-strain variation in cortical and trabecular traits during growth of the mouse lumbar vertebral body.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Article
- HBM Mice Have Altered Bone Matrix Composition and Improved Material Toughness.Calcified tissue international · 2016Article
- Establishing biomechanical mechanisms in mouse models: practical guidelines for systematically evaluating phenotypic changes in the diaphyses of long bones.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Review
- Genetic regulation of bone strength: a review of animal model studies.BoneKEy reports · 2015Review
- Characterization of complex, co-adapted skeletal biomechanics phenotypes: a needed paradigm shift in the genetics of bone structure and function.Current osteoporosis reports · 2014Article
- ENU mutation mapped to a distal region of chromosome 11 is a major determinant of bone size.Physiological genomics · 2013Article
- Intracortical bone remodeling variation shows strong genetic effects.Calcified tissue international · 2013Article
- Article
- Systematic evaluation of skeletal mechanical function.Current protocols in mouse biology · 2013Article
- The genetic profile of bone repair.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2013Article
- Dissection of complex adult traits in a mouse synthetic population.Genome research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Compensatory interactions among adult skeletal traits are critical for establishing strength but complicate the search for fracture susceptibility genes by allowing many genetic variants to exist in a population without loss of function. A better understanding of how these interactions arise during growth will provide new insight into genotype-phenotype relationships and the biological controls that establish skeletal strength. We tested the hypothesis that genetic variants affecting growth in width relative to growth in length (slenderness) are coordinated with movement of the inner bone surface and matrix mineralization to match stiffness with weight-bearing loads during postnatal growth. Midshaft femoral morphology and tissue-mineral density were quantified at ages of 1 day and at 4, 8, and 16 weeks for a panel of 20 female AXB/BXA recombinant inbred mouse strains. Path Analyses revealed significant compensatory interactions among outer-surface expansion rate, inner-surface expansion rate, and tissue-mineral density during postnatal growth, indicating that genetic variants affecting bone slenderness were buffered mechanically by the precise regulation of bone surface movements and matrix mineralization. Importantly, the covariation between morphology and mineralization resulted from a heritable constraint limiting the amount of tissue that could be used to construct a functional femur. The functional interactions during growth explained 56-99% of the variability in adult traits and mechanical properties. These functional interactions provide quantitative expectations of how genetic or environmental variants affecting one trait should be compensated by changes in other traits. Variants that impair this process or that cannot be fully compensated are expected to alter skeletal growth leading to underdesigned (weak) or overdesigned (bulky) structures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.