ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2009
Hexose transporter expression and function in mouse small intestine: role of diurnal rhythm.
Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Effects of Maternal Nutrition and One-Carbon Metabolite Supplementation on Fetal Jejunal Morphology and Hexose Transporter Expression in Beef Cattle.Veterinary sciences · 2025Article
- Physiological functions of glucose transporter-2: From cell physiology to links with diabetes mellitus.Heliyon · 2024Review
- Circadian rhythms of the mRNA abundances of clock genes and glucose transporters in the jejunum of weanling-growing pigs.Veterinary medicine and science · 2022Article
- Glucose transporters in the small intestine in health and disease.Pflugers Archiv : European journal of physiology · 2020Review
- BMAL1 controls glucose uptake through paired-homeodomain transcription factor 4 in differentiated Caco-2 cells.American journal of physiology. Cell physiology · 2019Article
- Serum Citrulline Levels Exhibit Circadian Variation and Fluctuations in Relation to Food Intake in Mice.Gastroenterology research · 2019Article
- Degree of SGLT1 phosphorylation is associated with but does not determine segment-specific glucose transport features in the porcine small intestines.Physiological reports · 2018Article
- Delphinidin Reduces Glucose Uptake in Mice Jejunal Tissue and Human Intestinal Cells Lines through FFA1/GPR40.International journal of molecular sciences · 2017Article
- Expression and regulation of the neutral amino acid transporter B0AT1 in rat small intestine.PloS one · 2017Article
- Circadian regulation of metabolic homeostasis: causes and consequences.Nature and science of sleep · 2016Review
- Reduction of intestinal electrogenic glucose absorption after duodenojejunal bypass in a mouse model.Obesity surgery · 2013Article
- Diurnal rhythmicity in biological processes involved in bioavailability of functional food factors.Journal of clinical biochemistry and nutrition · 2013Article
- Circadian clock genes and implications for intestinal nutrient uptake.The Journal of nutritional biochemistry · 2012Review
- Differentiating passive from transporter-mediated uptake by PepT1: a comparison and evaluation of four methods.The Journal of surgical research · 2011Article
- Absence of evidence of translocation of GLUT2 to the apical membrane of enterocytes in everted intestinal sleeves.The Journal of surgical research · 2011Article
- Role of vagal innervation in diurnal rhythm of intestinal peptide transporter 1 (PEPT1).Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2009Article
- Diurnal expression and function of peptide transporter 1 (PEPT1).The Journal of surgical research · 2009Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundExpression and function of hexose transporters vary diurnally in rat small intestine; however, this subject remains unexplored in mice.
aimThe aim of the study was to investigate the diurnal expression and function of hexose transporters SGLT1, GLUT2, and GLUT5 in mouse small bowel.
methodsTwenty-four c57bl6 mice maintained in a 12-h light/dark room (6 AM: -6 PM: ) were sacrificed at 9 AM: , 3 PM: , 9 PM: , and 3 AM: (n = 6 each). In duodenal, jejunal, and ileal mucosa, total cellular mRNA and protein levels were quantitated by real-time PCR and semiquantitative Western blotting, respectively. The everted sleeve technique measured transporter-mediated glucose uptake at 9 AM: and 9 PM: .
resultsmRNA expression of SGLT1, GLUT2, and GLUT5 varied diurnally in all three intestinal segments (p <or= 0.03). SGLT1, GLUT2, and GLUT5 protein levels varied diurnally in duodenum and jejunum (p < 0.05) but not in ileum. Transporter-mediated glucose uptake was greater at 9 PM: than 9 AM: (p <or= 0.04) in all three segments. V (max) was greater in duodenum (10 vs 6 nmol/cm/s) and jejunum (8 vs 5 nmol/cm/s) at 9 PM: compared to 9 AM: (p = 0.01); K (m) remained unchanged. mRNA levels of intestinal hexose transporters varied diurnally. Protein levels peaked 6-12 h later during dark cycle when >70% of food intake occurred; glucose transport followed a similar pattern with increased uptake at 9 PM: .
conclusionHexose transporter expression and function vary diurnally with nocturnal feeding patterns of mice.
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