ArticleBulletin of mathematical biology2009
Latent coinfection and the maintenance of strain diversity.
Article in Bulletin of mathematical biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Mycobacterium tuberculosis mixed infections and drug resistance in sub-Saharan Africa: a systematic review.African health sciences · 2022Pooled it
- Population-level mathematical modeling of antimicrobial resistance: a systematic review.BMC medicine · 2019Pooled it
- QuantTB - a method to classify mixed Mycobacterium tuberculosis infections within whole genome sequencing data.BMC genomics · 2020Article
- Global burden of latent multidrug-resistant tuberculosis: trends and estimates based on mathematical modelling.The Lancet. Infectious diseases · 2019Article
- Elucidating Transmission Patterns of EndemicVeterinary sciences · 2019Article
- ClassTR: Classifying Within-Host Heterogeneity Based on Tandem Repeats with Application to Mycobacterium tuberculosis Infections.PLoS computational biology · 2016Article
- How competition governs whether moderate or aggressive treatment minimizes antibiotic resistance.eLife · 2015Article
- How could preventive therapy affect the prevalence of drug resistance? Causes and consequences.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Magnitude and sources of bias in the detection of mixed strain M. tuberculosis infection.Journal of theoretical biology · 2015Article
- Mathematical Modelling and Tuberculosis: Advances in Diagnostics and Novel Therapies.Advances in medicine · 2015Review
- Drivers and trajectories of resistance to new first-line drug regimens for tuberculosis.Open forum infectious diseases · 2014Article
- Long term follow-up of drug resistant and drug susceptible tuberculosis contacts in a Low incidence setting.BMC infectious diseases · 2012Article
- Mixed-strain mycobacterium tuberculosis infections and the implications for tuberculosis treatment and control.Clinical microbiology reviews · 2012Review
- Translating basic science insight into public health action for multidrug- and extensively drug-resistant tuberculosis.Respirology (Carlton, Vic.) · 2012Review
- Modeling the dynamic relationship between HIV and the risk of drug-resistant tuberculosis.Science translational medicine · 2012Article
- Modelling the performance of isoniazid preventive therapy for reducing tuberculosis in HIV endemic settings: the effects of network structure.Journal of the Royal Society, Interface · 2011Article
- Models to understand the population-level impact of mixed strain M. tuberculosis infections.Journal of theoretical biology · 2011Article
- Mixed-strain Mycobacterium tuberculosis infections among patients dying in a hospital in KwaZulu-Natal, South Africa.Journal of clinical microbiology · 2011Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Technologies for strain differentiation and typing have made it possible to detect genetic diversity of pathogens, both within individual hosts and within communities. Coinfection of a host by more than one pathogen strain may affect the relative frequency of these strains at the population level through complex within- and between-host interactions; in infectious diseases that have a long latent period, interstrain competition during latency is likely to play an important role in disease dynamics. We show that SEIR models that include a class of latently coinfected individuals can have markedly different long-term dynamics than models without coinfection, and that coinfection can greatly facilitate the stable coexistence of strains. We demonstrate these dynamics using a model relevant to tuberculosis in which people may experience latent coinfection with both drug sensitive and drug resistant strains. Using this model, we show that the existence of a latent coinfected state allows the possibility that disease control interventions that target latency may facilitate the emergence of drug resistance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.