ReviewOncology reports2009
Surfactant protein DNA methylation: a new entrant in the field of lung cancer diagnostics? (Review).
Review in Oncology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Serum Folate Levels and Lung Cancer Risk: A Meta- Epidemiological Study of Population-based Case-Control Studies.Asian Pacific journal of cancer prevention : APJCP · 2020Pooled it
- Prognostic Significance of PTTG1 and Its Methylation in Lung Adenocarcinoma.Journal of oncology · 2022Article
- Necessity of Epigenetic Epidemiology Studies on the Carcinogenesis of Lung Cancer in Never Smokers.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2018Article
- DNA methylation profile and expression of surfactant protein A2 gene in lung cancer.Experimental lung research · 2015Article
- Review
- A gene expression profile test to resolve head & neck squamous versus lung squamous cancers.Diagnostic pathology · 2013Article
- RUNX3 is involved in caspase-3-dependent apoptosis induced by a combination of 5-aza-CdR and TSA in leukaemia cell lines.Journal of cancer research and clinical oncology · 2012Article
- Air pollution and epigenetics: effects on SP-A and innate host defence in the lung.Swiss medical weekly · 2012Review
- Inhibitory effects of megakaryocytic cells in prostate cancer skeletal metastasis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- High resolution detection and analysis of CpG dinucleotides methylation using MBD-Seq technology.PloS one · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Lung cancer is a major cause of cancer-related mortality in both men and women. A 5-year survival of lung cancer patients is only 15% with a negative correlation between progressively advanced lung cancer stage and a 5-year survival period. The only chance for cure is surgical resection if done at the early stage of the disease. Therefore, an early diagnosis and a better prediction of prognosis could decrease mortality. An early diagnosis could provide the opportunity for a therapeutic intervention early in the course of the disease. Genetic alterations in the cancer genome include aneuploidy, deletions and amplifications of chromosomal regions, loss of heterozygosity (LOH), microsatellite alterations, point mutations and aberrant promoter methylation. Of the various types of genetic alterations (i.e. gene amplifications, allele deletions, point mutations or deletions and methylation) reported in different tumor types, aberrant promoter methylation of genes is recent and is the focus of the present review. Specifically, we will briefly review the role of promoter methylation in various malignancies and then focus on lung cancer diagnosis and promoter gene methylation with emphasis on the methylation status of genes of the innate host defense, namely the surfactant proteins A and D.
Indexed as
Identifiers
19082436PMC2899699W2135895010What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.