Evidence map›Paper›PMID 19081825›Full record

ArticleDrug discovery today. Disease mechanisms2007

Defensive strategies of Bacillus anthracis that promote a fatal disease.

Jeremy Mogridge

Open access · greenAbstract read
In one paragraph

Article in Drug discovery today. Disease mechanisms, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Genetic diversity and virulence ofMicrobiology spectrum · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Jeremy MogridgeDepartment of Laboratory Medicine and Pathobiology, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
University of Toronto · CA

Funding

Development and testing of polyvalent anthrax toxin inhibitorsU01AI056546 · NIAID · UNIVERSITY OF TORONTO · PI MOGRIDGE, JEREMY S · 2003 to 2012
$11.4M
Characterization of Anthrax Lethal ToxinR01AI067683 · NIAID · UNIVERSITY OF TORONTO · PI MOGRIDGE, JEREMY S · 2006 to 2010
$1.3M
NIAID NIH HHS R01 AI067683NIAID NIH HHS U01 AI056546
6 · The paper itself

Abstract

Bacillus anthracis is a Gram-positive bacterium that causes anthrax. Bacterial spores that enter the host germinate into metabolically active bacilli that disseminate throughout the body and replicate to high numbers. Two virulence factors are essential for this unrestrained growth. The first is a weakly immunogenic poly gamma-D-glutamic acid capsule that surrounds the bacilli and confers resistance to phagocytosis. The second virulence factor, anthrax toxin, disrupts multiple host functions to diminish the immune response.

Identifiers

PMID19081825
PMCPMC2597864
OpenAlexW2084199901

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.