Evidence map›Paper›PMID 19081818›Full record

ArticleDrug discovery today. Disease mechanisms2007

Myocardial Regeneration by Exogenous and Endogenous Progenitor Cells.

Annarosa Leri, Toru Hosoda, Marcello Rota, Jan Kajstura, Piero Anversa

Abstract read
In one paragraph

Article in Drug discovery today. Disease mechanisms, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Skeletal myoblasts for cardiac repair.Regenerative medicine · 2010
    Review
  6. Telocytes in human epicardium.Journal of cellular and molecular medicine · 2010
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Annarosa LeriDepartments of Anesthesia and Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
Toru Hosoda
Marcello Rota
Jan Kajstura
Piero Anversa

Funding

Stem Cells and Cardiac AgingP01AG023071 · NIA · NEW YORK MEDICAL COLLEGE · PI SUSSMAN, MARK ALAN · 2004 to 2008
$9.5M
Repair and Angiogenesis by Stem Cells in Human HeartR37HL081737 · NHLBI · NEW YORK MEDICAL COLLEGE · PI ANVERSA, PIERO · 2005 to 2015
$6.5M
IGF-1, Gender, Heart Failure and Longevity: A Paradigm ShiftR01AG017042 · NIA · NEW YORK MEDICAL COLLEGE · PI ANVERSA, PIERO · 2000 to 2010
$5.3M
Coronary Vasculature Progenitor Cell in Human Ischemic Heart FailureR01HL039902 · NHLBI · NEW YORK UNIVERSITY · PI ANVERSA, PIERO, KAJSTURA, JAN · 1989 to 2012
$4.7M
MYOCYTE STEM CELLS IN THE MAMMALIAN HEARTR01HL065577 · NHLBI · NEW YORK MEDICAL COLLEGE · PI LERI, ANNAROSA · 2000 to 2012
$2.9M
Redefining Human Myocardial BiologyR01HL105532 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ANVERSA, PIERO, BUCHHOLZ, BRUCE A · 2011 to 2014
$2.2M
IGF-1 and Diabetic HeartR01HL065573 · NHLBI · NEW YORK MEDICAL COLLEGE · PI KAJSTURA, JAN · 2001 to 2010
$2.1M
Cardiac Stem Cell Growth, Aging and DeathR01HL075480 · NHLBI · NEW YORK MEDICAL COLLEGE · PI KAJSTURA, JAN · 2004 to 2008
$1.9M
Cardiac Stem Cells and AngiomyogenesisR01HL111183 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LERI, ANNAROSA · 2012 to 2015
$1.7M
Aging and Homeostasis of Cardiac Stem Cell NichesR01AG026107 · NIA · NEW YORK MEDICAL COLLEGE · PI LERI, ANNAROSA · 2006 to 2010
$1.7M
NHLBI NIH HHS R01 HL039902NHLBI NIH HHS R01 HL065573NHLBI NIH HHS R01 HL065577NHLBI NIH HHS R01 HL075480NHLBI NIH HHS R01 HL111183NHLBI NIH HHS R37 HL081737NIA NIH HHS P01 AG023071NIA NIH HHS R01 AG017042NIA NIH HHS R01 AG026107
6 · The paper itself

Abstract

A problem in need of resolution concerns the origin of cardiac progenitor cells and the mechanisms by which these cells are preserved within the cardiac niches. This may be accomplished by migration of progenitor cells from the bone marrow to the myocardium. Alternatively, the progenitor cell compartment in the heart may be maintained by asymmetric division of resident cells. These two possibilities are not mutually exclusive and both exogenous and endogenous progenitor cells may contribute to cardiac homeostasis.

Identifiers

PMID19081818
PMCPMC2597844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.