ArticleThe journal of physical chemistry. C, Nanomaterials and interfaces2007
The Role of Glycocalyx in Nanocarrier-Cell Adhesion Investigated Using a Thermodynamic Model and Monte Carlo Simulations.
Article in The journal of physical chemistry. C, Nanomaterials and interfaces, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 45 citations in OpenAlex.
- Mechanical regulation of extracellular vesicle activity during tumour progression.Nature biomedical engineering · 2025Review
- Selective Integrin αMolecules (Basel, Switzerland) · 2022Article
- Multiphysics pharmacokinetic model for targeted nanoparticles.Frontiers in medical technology · 2022Article
- Understanding the Role of Endothelial Glycocalyx in Mechanotransduction via Computational Simulation: A Mini Review.Frontiers in cell and developmental biology · 2021Review
- Multiscale modeling of protein membrane interactions for nanoparticle targeting in drug delivery.Current opinion in structural biology · 2020Review
- Article
- Mechanotransmission of haemodynamic forces by the endothelial glycocalyx in a full-scale arterial model.Royal Society open science · 2019Article
- Stiffness can mediate balance between hydrodynamic forces and avidity to impact the targeting of flexible polymeric nanoparticles in flow.Nanoscale · 2019Article
- Multivalent Binding of a Ligand-Coated Particle: Role of Shape, Size, and Ligand Heterogeneity.Biophysical journal · 2018Article
- Structure and elasticity of bush and brush-like models of the endothelial glycocalyx.Scientific reports · 2018Article
- Computational Models for Nanoscale Fluid Dynamics and Transport Inspired by Nonequilibrium Thermodynamics.Journal of heat transfer · 2017Article
- Biophysically inspired model for functionalized nanocarrier adhesion to cell surface: roles of protein expression and mechanical factors.Royal Society open science · 2016Article
- Non-affinity factors modulating vascular targeting of nano- and microcarriers.Advanced drug delivery reviews · 2016Review
- Receptor-mediated membrane adhesion of lipid-polymer hybrid (LPH) nanoparticles studied by dissipative particle dynamics simulations.Nanoscale · 2015Article
- Article
- Modelling of Binding Free Energy of Targeted Nanocarriers to Cell Surface.Heat and mass transfer = Warme- und Stoffubertragung · 2014Article
- Structure and response to flow of the glycocalyx layer.Biophysical journal · 2014Article
- Temporal Multiscale Approach for Nanocarrier Motion with Simultaneous Adhesion and Hydrodynamic Interactions in Targeted Drug Delivery.Journal of computational physics · 2013Article
- Reduction of nanoparticle avidity enhances the selectivity of vascular targeting and PET detection of pulmonary inflammation.ACS nano · 2013Article
- Nanocarrier Hydrodynamics and Binding in Targeted Drug Delivery: Challenges in Numerical Modeling and Experimental Validation.Journal of nanotechnology in engineering and medicine · 2013Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We present an equilibrium model for quantifying the effect of glycocalyx in mediating the interaction of functionalized nanocarriers with endothelial cells. In this model, nanocarrier adhesion is governed by the interplay between three physical parameters, namely, glycocalyx resistance, flexural rigidity of receptors, and receptor-ligand bond stiffness. We describe a procedure to rationally determine the values of these crucial parameters based on several independent (single molecule and cell-based) characterizing experiments. Using our model and independent derivation of the parameter values in conjunction with Monte Carlo simulations, we describe the binding of nanocarriers to endothelial cells at equilibrium. We show that we can quantitatively reproduce the experimental binding affinities with zero fitting to binding data. Additionally, our simulations provide quantitative descriptions for the multivalency in nanocarrier binding, as well as for the degree of clustering of antigens. Our study identifies two interesting parameters: glycocalyx resistance and antigen flexural rigidity, both of which reduce binding of nanocarriers and alter the sensitivity of the nanocarrier binding constant to changes in temperature. Collectively, our model, parameter estimations, simulations, and sensitivity analyses help provide unified molecular and energetic analyses of the nanocarrier binding process.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.