ArticleDevelopmental cell2008
The conserved protein SZY-20 opposes the Plk4-related kinase ZYG-1 to limit centrosome size.
Article in Developmental cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Distinct D-box motifs in SPD-2 mediate APC/CFZR-1-dependent degradation and centrosomal localization in Caenorhabditis elegans embryos.G3 (Bethesda, Md.) · 2026Article
- METTL14 promotes trophoblast dysfunction by elevating SZRD1 expression in an m6A-dependent manner.Human cell · 2026Article
- RNA-binding protein LARP6 coordinates hepatic stellate cell activation and liver fibrosis.The Journal of clinical investigation · 2026Article
- The Functional Role of S280 within the ZYG-1 Phosphorylation Cluster During Centrosome Assembly inmicroPublication biology · 2026Article
- Distinct D-box Motifs in SPD-2 Mediate APC/CbioRxiv : the preprint server for biology · 2025Article
- Site-specific phosphorylation of ZYG-1 regulates ZYG-1 stability and centrosome number.iScience · 2023Article
- Article
- A combinedCell cycle (Georgetown, Tex.) · 2022Article
- APC/CFZR-1 regulates centrosomal ZYG-1 to limit centrosome number.Journal of cell science · 2021Article
- The Identification and Functional Analysis of mRNA Localizing to Centrosomes.Frontiers in cell and developmental biology · 2021Review
- PRD-2 directly regulateseLife · 2020Article
- The expression of Rpb10, a small subunit common to RNA polymerases, is modulated by the R3H domain-containing Rbs1 protein and the Upf1 helicase.Nucleic acids research · 2020Article
- Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity.Nature communications · 2019Article
- Mitotic Cell Division inGenetics · 2019Review
- CDK-11-Cyclin L is required for gametogenesis and fertility in C. elegans.Developmental biology · 2018Article
- Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly.Nature communications · 2018Article
- The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts.Nature communications · 2018Article
- APC/CG3 (Bethesda, Md.) · 2017Article
- The La and related RNA-binding proteins (LARPs): structures, functions, and evolving perspectives.Wiley interdisciplinary reviews. RNA · 2017Review
- Article
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4 authors.
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Abstract
Microtubules are organized by the centrosome, a dynamic organelle that exhibits changes in both size and number during the cell cycle. Here we show that SZY-20, a putative RNA-binding protein, plays a critical role in limiting centrosome size in C. elegans. SZY-20 localizes in part to centrosomes and in its absence centrosomes possess increased levels of centriolar and pericentriolar components including gamma-tubulin and the centriole duplication factors ZYG-1 and SPD-2. These enlarged centrosomes possess normal centrioles, nucleate more microtubules, and fail to properly direct a number of microtubule-dependent processes. Depletion of ZYG-1 restores normal centrosome size and function to szy-20 mutants, whereas loss of szy-20 suppresses the centrosome duplication defects in both zyg-1 and spd-2 mutants. Our results describe a pathway that determines centrosome size and implicate centriole duplication factors in this process.
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