Evidence map›Paper›PMID 19080750›Full record

ReviewCurrent neurology and neuroscience reports2009

The interface between stroke and infectious disease: infectious diseases leading to stroke and infections complicating stroke.

Georgios Manousakis, Matthew B Jensen, Marcus R Chacon, Justin A Sattin, Ross L Levine

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current neurology and neuroscience reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 49 citations in OpenAlex.

  1. Associations of long-term exposure to source-specific PMEuropean archives of psychiatry and clinical neuroscience · 2026
    Article
  2. Stroke from Infection.Cerebrovascular diseases extra · 2025
    Review
  3. Observational
  4. Article
  5. Article
  6. Review
  7. Review
  8. Neurological complications and infection mechanism of SARS-COV-2.Signal transduction and targeted therapy · 2021
    Review
  9. Article
  10. Neurological Sequelae in Patients with COVID-19: A Histopathological Perspective.International journal of environmental research and public health · 2021
    Review
  11. Severe Neurologic Complications of SARS-CoV-2.Current treatment options in neurology · 2021
    Review
  12. Review
  13. The nervous system-A new territory being explored of SARS-CoV-2.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2020
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Georgios ManousakisDepartment of Neurology, University of Wisconsin School of Medicine and Public Health, H6/574 Clinical Sciences Center, 600 Highland Avenue, Madison, WI 53792, USA.
Matthew B Jensen
Marcus R Chacon
Justin A Sattin
Ross L Levine
University of Wisconsin–Madison · USHighland Community College - Illinois · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is well established that several infectious diseases can directly lead to ischemic or hemorrhagic stroke during their course. It appears possible that common viral and bacterial infections can increase the susceptibility to stroke by promoting atherosclerosis, inflammation, and local thrombosis. Stroke commonly leads to disruption of protective mechanisms against infection and induces a cascade of anti-inflammatory and immunosuppressive reactions, which greatly increases the risk of infection. The social and economic costs of post-stroke infections and their impact on stroke morbidity and outcome are dramatic. Understanding the pathophysiologic links between stroke and infection is therefore of paramount importance, and effective preventive strategies to reduce the risk of infection are needed. This article summarizes current clinical and experimental data regarding the interactions between stroke and infection and outlines possible targets for therapeutic intervention.

Indexed as

StrokeAnimalsCommunicable DiseasesHumans

Identifiers

PMID19080750
OpenAlexW2020042013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.