Evidence map›Paper›PMID 19080745›Full record

ReviewCurrent oncology reports2009

Insights into the biology of primary central nervous system lymphoma.

Maciej M Mrugala, James L Rubenstein, Maurilio Ponzoni, Tracy T Batchelor

Abstract readReview
In one paragraph

Review in Current oncology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Demographics, Pattern of Care & Outcomes of Primary CNS Lymphoma- Experience from a Tertiary Care Cancer Center in India.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2023
    Article
  2. Lymphomas of Central Nervous System.Advances in experimental medicine and biology · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. The Challenge of Primary Central Nervous System Lymphoma.Hematology/oncology clinics of North America · 2016
    Review
  13. Article
  14. Article
  15. Article
  16. Imaging and therapy with rituximab anti-CD20 immunotherapy in an animal model of central nervous system lymphoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2011
    Article
  17. Selective central nervous system tropism of primary central nervous system lymphoma.International journal of clinical and experimental pathology · 2010
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maciej M MrugalaStephen E and Catherine Pappas Center for Neuro-Oncology, Yawkey 9E, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.
James L Rubenstein
Maurilio Ponzoni
Tracy T Batchelor

Funding

The Role of Interleukin-4 (IL-4) in the Pathogenesis of Non-Hodgkin's LymphomaR01CA139083 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUBENSTEIN, JAMES LOUIS · 2009 to 2018
$3.4M
Molecular Classification and Therapy of CNS LymphomasK23CA100291 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RUBENSTEIN, JAMES LOUIS · 2004 to 2008
$635k
Annual Primary CNS Lymphoma Collaborative Group MeetingR13CA124293 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BATCHELOR, TRACY T · 2006 to 2019
$62k
NCI NIH HHS K23 CA100291NCI NIH HHS R01 CA139083NCI NIH HHS R13 CA124293
6 · The paper itself

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare variant of non-Hodgkin lymphoma that is confined to the central nervous system. Biologic studies of PCNSL are challenging to conduct because the disease is rare and available tissue material is sparse. However, in recent years there has been progress in the understanding of PCNSL biology, largely as the result of multicenter studies using modern molecular techniques. Recent studies may improve insight into the pathogenesis of PCNSL and increase the chances of identifying prognostic factors and novel therapeutic targets. This review discusses recent advances in PCNSL biology, including immunologic and genetic risk factors, and focuses on the molecular alterations important in central nervous system lymphomagenesis.

Indexed as

Biomarkers, TumorCell Transformation, NeoplasticCentral Nervous System NeoplasmsGene Expression ProfilingHerpesvirus 4, HumanHumansImmunohistochemistryImmunophenotypingLymphoma, Non-HodgkinMedical OncologyModels, BiologicalModels, GeneticMutationPrognosisRisk FactorsBiomarkers, Tumor

Identifiers

PMID19080745
PMCPMC4110181

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.