ArticleJournal of molecular evolution1991
Evolution of the rat kallikrein gene family: gene conversion leads to functional diversity.
Article in Journal of molecular evolution, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 64 citations in OpenAlex.
- Genome Wide Identification, Evolutionary, and Expression Analysis of VQ Genes from Two Pyrus Species.Genes · 2018Article
- Article
- The role of gene conversion in determining sequence variation and divergence in the Est-5 gene family in Drosophila pseudoobscura.Genetics · 1998Article
- Differences in the glycosylation of rat submandibular kallikreins.Glycoconjugate journal · 1996Article
- On hypervariability at the reactive center of proteolytic enzymes and their inhibitors.Journal of molecular evolution · 1994Article
- Structure of homeobox-leucine zipper genes suggests a model for the evolution of gene families.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Purification of enzymes of the kallikrein gene family (rK8 and rK9) from the rat prostate.The Biochemical journal · 1994Article
- Molecular aspects of kallikrein and kininogen in the maturing kidney.Pediatric nephrology (Berlin, Germany) · 1993Review
- Expression and characterization of rat kallikrein-binding protein in Escherichia coli.The Biochemical journal · 1993Article
- The evolutionary relationship of avian and mammalian myosin heavy-chain genes.Journal of molecular evolution · 1993Article
- Genes of the major histocompatibility complex and the evolutionary genetics of lifespan.Genetica · 1993Review
- Simulation study of a multigene family, with special reference to the evolution of compensatory advantageous mutations.Genetics · 1992Article
- Characterization of a new kallikrein-like enzyme (KLP-S3) of the rat submandibular gland.The Biochemical journal · 1992Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Kallikrein-like simple serine proteases are encoded by closely related members of a gene family in several mammalian species. Molecular cloning and genomic Southern blot analysis after conventional and pulsed-field gel electrophoresis indicate that the rat kallikrein gene family comprises 15-20 members, probably closely linked at a single locus. Determination of the nucleotide sequences of the rGK-3, -4, and -6 genes here completes sequence data for a total of nine rat kallikrein family members. Comparison of the rat gene sequences to each other and to those of human and mouse kallikrein family genes reveals patterns of relatedness indicative of concerted evolution. Analysis of nucleotide sequence variants in kallikrein family members shows that most sequence variants are shared by multiple family members; the patterns of shared variants are complex and indicate multiple short gene conversions between family members. Sequence exchanges between family members generate novel assortments of variants in amino acid coding regions that may affect substrate specificity and thereby contribute to the diversity of enzyme activity. Furthermore, small sequence exchanges also may play a role in generating the diverse patterns of tissue-specific expression of rat family members. These analyses indicate an important role for gene conversion in the evolution of the functional diversity of these duplicated genes.
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