ReviewThe British journal of nutrition2009
Nutrition in early life, and risk of cancer and metabolic disease: alternative endings in an epigenetic tale?
Review in The British journal of nutrition, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 85 citations in OpenAlex.
- Trial
- Women exposed to famine in early gestation have increased mortality up to age 76 years.Paediatric and perinatal epidemiology · 2025Article
- Integration of sperm ncRNA-directed DNA methylation and DNA methylation-directed histone retention in epigenetic transgenerational inheritance.Epigenetics & chromatin · 2021Article
- Folate Deficiency Inhibits Development of the Mammary Gland and its Associated Lymphatics in FVB Mice.The Journal of nutrition · 2020Article
- Markers as mediators: A review and synthesis of epigenetics literature.BioSocieties · 2019Article
- Alterations in sperm DNA methylation, non-coding RNA expression, and histone retention mediate vinclozolin-induced epigenetic transgenerational inheritance of disease.Environmental epigenetics · 2018Article
- Milk's Role as an Epigenetic Regulator in Health and Disease.Diseases (Basel, Switzerland) · 2017Review
- Understanding and effectively addressing breast cancer in African American women: Unpacking the social context.Cancer · 2016Review
- Elusive inheritance: Transgenerational effects and epigenetic inheritance in human environmental disease.Progress in biophysics and molecular biology · 2015Review
- Exposure to early adversity: Points of cross-species translation that can lead to improved understanding of depression.Development and psychopathology · 2015Review
- Maternal undernutrition and cardiometabolic disease: a Latin American perspective.BMC medicine · 2015Article
- Social exclusion changes histone modifications H3K4me3 and H3K27ac in liver tissue of wild house mice.PloS one · 2015Article
- From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?Clinical epigenetics · 2015Article
- Article
- Is fetal macrosomia related to blood pressure among adolescents? A birth cohort study in China.Journal of human hypertension · 2013Article
- Placental glucose transporter 3 (GLUT3) is up-regulated in human pregnancies complicated by late-onset intrauterine growth restriction.Placenta · 2013Article
- Early life exposure to the 1918 influenza pandemic and old-age mortality by cause of death.American journal of public health · 2013Article
- Exposures in early life: associations with DNA promoter methylation in breast tumors.Journal of developmental origins of health and disease · 2013Article
- Early life nutrient restriction impairs blood-brain metabolic profile and neurobehavior predisposing to Alzheimer's disease with aging.Brain research · 2013Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
There is substantial evidence which shows that constraints in the early life environment are an important determinant of risk of metabolic disease and CVD. There is emerging evidence that higher birth weight, which reflects a more abundant prenatal environment, is associated with increased risk of cancer, in particular breast cancer and childhood leukaemia. Using specific examples from epidemiology and experimental studies, this review discusses the hypothesis that increased susceptibility to CVD, metabolic disease and cancer have a common origin in developmental changes induced in the developing fetus by aspects of the intra-uterine environment including nutrition which involve stable changes to the epigenetic regulation of specific genes. However, the induction of specific disease risk is dependent upon the nature of the environmental challenge and interactions between the susceptibility set by the altered epigenome and the environment throughout the life course.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.