ArticlePsychological medicine2009
Neurocognitive impairment in unaffected siblings of youth with bipolar disorder.
Article in Psychological medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Neurocognitive functioning in euthymic patients with bipolar disorder and unaffected relatives: A review of the literature.Neuroscience and biobehavioral reviews · 2016Pooled it
- Norepinephrine and impulsivity: effects of acute yohimbine.Psychopharmacology · 2013Trial
- Neurocognitive Biotypes of Risk and Resilience for Mood Disorders in Adolescents: Insights From Behavioral and Graph-Theoretic Network Markers.Biological psychiatry global open science · 2025Article
- Cognitive Correlates of Borderline Personality Disorder Features in Youth with Bipolar Spectrum Disorders and Bipolar Offspring.Brain sciences · 2025Article
- Childhood trauma and neurocognitive functions in individuals with bipolar disorder and unaffected siblings of individuals with bipolar disorder.Neuroscience applied · 2023Article
- Processing speed - A potential candidate cognitive endophenotype for bipolar disorder.Journal of affective disorders reports · 2023Article
- MICEmi: A method to identify cognitive endophenotypes of mental illnesses.European psychiatry : the journal of the Association of European Psychiatrists · 2022Review
- Evaluating endophenotypes for bipolar disorder.International journal of bipolar disorders · 2021Review
- Attention Deficits in a Comorbidity-Free Sample of Euthymic Pediatric Bipolar Disorder.Frontiers in psychiatry · 2019Article
- Cross-Disorder Cognitive Impairments in Youth Referred for Neuropsychiatric Evaluation.Journal of the International Neuropsychological Society : JINS · 2018Article
- Staging, Neurocognition and Social Functioning in Bipolar Disorder.Frontiers in psychiatry · 2018Article
- Intellectual Functioning in Offspring of Parents with Bipolar Disorder: A Review of the Literature.Brain sciences · 2017Review
- Prediction of vulnerability to bipolar disorder using multivariate neurocognitive patterns: a pilot study.International journal of bipolar disorders · 2017Article
- Cognitive Performance in Euthymic Patients with Bipolar Disorder vs Healthy Controls: A Neuropsychological Investigation.Clinical practice and epidemiology in mental health : CP & EMH · 2017Article
- Neurobiology of Risk for Bipolar Disorder.Current treatment options in psychiatry · 2016Review
- Neuro-cognitive functioning in unaffected siblings of patients with bipolar disorder: Comparison with bipolar patients and healthy controls.Indian journal of psychiatry · 2014Article
- A diagnostic model incorporating P50 sensory gating and neuropsychological tests for schizophrenia.PloS one · 2013Article
- Negative emotion impairs working memory in pediatric patients with bipolar disorder type I.Psychological medicine · 2012Article
- Memory in early onset bipolar disorder and attention-deficit/hyperactivity disorder: similarities and differences.Journal of abnormal child psychology · 2012Article
- Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder.Progress in neuro-psychopharmacology & biological psychiatry · 2012Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThere is growing evidence for the familiality of pediatric bipolar disorder (BPD) and its association with impairments on measures of processing speed, verbal learning and 'executive' functions. The current study investigated whether these neurocognitive impairments index the familial risk underlying the diagnosis.
methodSubjects were 170 youth with BPD (mean age 12.3 years), their 118 non-mood-disordered siblings and 79 non-mood-disordered controls. Groups were compared on a battery of neuropsychological tests from the Wechsler Intelligence Scales, the Stroop Color Word Test, the Wisconsin Card Sorting Test (WCST), the Rey-Osterrieth Complex Figure (ROCF), an auditory working memory Continuous Performance Test (CPT) and the California Verbal Learning Test-Children's Version (CVLT-C). Measures were factor analyzed for data reduction purposes. All analyses controlled for age, sex and attention-deficit/hyperactivity disorder (ADHD).
resultsPrincipal components analyses with a promax rotation yielded three factors reflecting: (1) processing speed/verbal learning, (2) working memory/interference control and (3) abstract problem solving. The CPT working memory measure with interference filtering demands (WM INT) was only administered to subjects aged > or =12 years and was therefore analyzed separately. BPD youth showed impairments versus controls and unaffected relatives on all three factors and on the WM INT. Unaffected relatives exhibited impairments versus controls on the abstract problem-solving factor and the WM INT. They also showed a statistical trend (p=0.07) towards worse performance on the working memory/interference control factor.
conclusionsNeurocognitive impairments in executive functions may reflect the familial neurobiological risk mechanisms underlying pediatric BPD and may have utility as endophenotypes in molecular genetic studies of the condition.
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Registered trials
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