ArticleBiomarker insights2008
The role of thrombospondin 1 on intestinal inflammation and carcinogenesis.
Article in Biomarker insights, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Article
- Article
- Cell-Free Therapies: The Use of Cell Extracts to Mitigate Irradiation-Injured Salivary Glands.Biology · 2023Review
- Epithelial CD47 is critical for mucosal repair in the murine intestine in vivo.Nature communications · 2019Article
- Mass spectrometry identification of potential biomarker proteins in the 150-kD electrophoretic band in patients with schizophrenia.Medicine · 2018Article
- Thrombospondin-1 and microRNA-1 expression in response to multiwalled carbon nanotubes in alveolar epithelial cells.Environmental toxicology · 2017Article
- Perindopril Induces TSP-1 Expression in Hypertensive Patients with Endothelial Dysfunction in Chronic Treatment.International journal of molecular sciences · 2017Article
- Thrombospondin-1 Partly Mediates the Cartilage Protective Effect of Adipose-Derived Mesenchymal Stem Cells in Osteoarthritis.Frontiers in immunology · 2017Article
- Thrombospondin-1 might be a therapeutic target to suppress RB cells by regulating the DNA double-strand breaks repair.Oncotarget · 2016Article
- Extensive surface protein profiles of extracellular vesicles from cancer cells may provide diagnostic signatures from blood samples.Journal of extracellular vesicles · 2016Article
- Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model.World journal of gastroenterology · 2015Article
- Angiogenesis in Inflammatory Bowel Disease.International journal of inflammation · 2015Review
- Longitudinal study of circulating protein biomarkers in inflammatory bowel disease.Journal of proteomics · 2015Article
- Whole-genome microarray analysis and functional characterization reveal distinct gene expression profiles and patterns in two mouse models of ileal inflammation.BMC genomics · 2012Article
- Extracellular matrix proteins modulate antimigratory and apoptotic effects of Doxorubicin.Chemotherapy research and practice · 2012Article
- Thrombospondin-1 and VEGF in inflammatory bowel disease.The Libyan journal of medicine · 2012Article
- Thrombospondin-1: multiple paths to inflammation.Mediators of inflammation · 2011Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Crohn's disease and ulcerative colitis are inflammatory bowel diseases (IBD) quite common in the United States and other Western countries. Patients suffering IBD are at greater risk of developing colorectal adenocarcinoma than the general population. Both, the adenoma-carcinoma and the inflammation-carcinogenesis processes are characterized by active angiogenesis. Recent studies also have shown that anti-angiogenesis might be a novel therapeutic approach for IBD. Thrombospondin 1 (TSP1) is an extracellular protein well known for its anti-angiogenic properties. TSP1 also has key functions in inflammation, which is assumed to be the primary cause for carcinogenesis in IBD. This review is focused on the role of TSP1 in colorectal carcinogenesis. The therapeutic effects of TSP derived-peptides on inhibiting the inflammationcarcinogenesis progression are also discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.