ArticleInternational journal of clinical and experimental medicine2008
Stem cells, phenotypic inversion, and differentiation.
Article in International journal of clinical and experimental medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Amino acid-induced regulation of hepatocyte growth: possible role of Drosha.Cell death & disease · 2019Article
- Physiologically normal 5% O2 supports neuronal differentiation and resistance to inflammatory injury in neural stem cell cultures.Journal of neuroscience research · 2015Article
- The Warburg effect: evolving interpretations of an established concept.Free radical biology & medicine · 2015Review
- Comparison of phenotype and differentiation marker gene expression profiles in human dental pulp and bone marrow mesenchymal stem cells.European journal of dentistry · 2014Article
- Cancer stem cell theory and the warburg effect, two sides of the same coin?International journal of molecular sciences · 2014Article
- Do dental stem cells depict distinct characteristics? - Establishing their "phenotypic fingerprint".Dental research journal · 2014Review
- Permeability transition pore-mediated mitochondrial superoxide flashes regulate cortical neural progenitor differentiation.PloS one · 2013Article
- Article
- Staying alive: metabolic adaptations to quiescence.Cell cycle (Georgetown, Tex.) · 2012Review
- Mitochondrial DNA and inflammatory diseases.Human genetics · 2012Review
- Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue.Journal of cellular and molecular medicine · 2011Article
- Stem cells and neuroprotection: understanding the players.International journal of molecular sciences · 2010Review
- The lineage-c-Kit+Sca-1+ cell response to Escherichia coli bacteremia in Balb/c mice.Stem cells (Dayton, Ohio) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Stem cells possess the potential to cure a myriad of ailments ranging from congenital diseases to illnesses acquired through the physiological process of aging. In the adult, these cells are extremely rare and often difficult to isolate in numbers sufficient to apply to medical treatment. Ex vivo expansion of these cells will be required for most meaningful interventions. The discovery of stem/progenitor cell inversion offers a new avenue for obtaining sufficient numbers of stem cells. Adult progenitor cells are much more common than quiescent stem cells and can be isolated with minimal interventions; therefore, inversion of progenitors to stem cells may become a feasible approach for therapeutic purposes. Stem cells are known to possess few mitochondria, and mitochondrial biogenesis is required for stem cell differentiation. The microtubule cytoskeleton is a major regulator for mitochondrial biogenesis. Investigations in the area of controlling cell differentiation and inducing phenotypic inversion, possibly through manipulation of mitochondrial biogenesis, may contribute to stem cell-based therapies.
Indexed as
Identifiers
19079683PMC2596332What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.