ArticleJournal of crystal growth2007
The nucleation and growth of calcium phosphate by amelogenin.
Article in Journal of crystal growth, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 83 citations in OpenAlex.
- Advances in biomineralization-inspired materials for hard tissue repair.International journal of oral science · 2021Review
- Mineralization of calcium phosphate controlled by biomimetic self-assembled peptide monolayers via surface electrostatic potentials.Bioactive materials · 2020Article
- Co-Immunoprecipitation Reveals Interactions Between Amelogenin and AmeloblastinFrontiers in physiology · 2020Article
- Novel Insights into Regulation of Human Teeth Biomineralization: Deciphering the Role of Post-Translational Modifications in a Tooth Protein Extract.International journal of molecular sciences · 2019Article
- Control of Calcium Phosphate Nucleation and Transformation through Interactions of Enamelin and Amelogenin Exhibits the "Goldilocks Effect".Crystal growth & design · 2018Article
- Remineralization Efficacy of an Amelogenin-Based Synthetic Peptide on Carious Lesions.Frontiers in physiology · 2018Article
- Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Dynamic interactions of amelogenin with hydroxyapatite surfaces are dependent on protein phosphorylation and solution pH.Colloids and surfaces. B, Biointerfaces · 2016Article
- Sequence-Defined Energetic Shifts Control the Disassembly Kinetics and Microstructure of Amelogenin Adsorbed onto Hydroxyapatite (100).Langmuir : the ACS journal of surfaces and colloids · 2015Article
- The leucine-rich amelogenin protein (LRAP) is primarily monomeric and unstructured in physiological solution.Journal of structural biology · 2015Article
- Amelogenin in Enamel Tissue Engineering.Advances in experimental medicine and biology · 2015Article
- Improved protocol to purify untagged amelogenin - Application to murine amelogenin containing the equivalent P70→T point mutation observed in human amelogenesis imperfecta.Protein expression and purification · 2015Article
- A novel oligopeptide simulating dentine matrix protein 1 for biomimetic mineralization of dentine.Clinical oral investigations · 2014Article
- Modeling biominerals formed by apatites and DNA.Biointerphases · 2013Article
- Revisiting the Fundamentals in the Design and Control of Nanoparticulate Colloids in the Frame of Soft Chemistry.Review journal of chemistry · 2013Article
- A solution NMR investigation into the impaired self-assembly properties of two murine amelogenins containing the point mutations T21→I or P41→T.Archives of biochemistry and biophysics · 2013Article
- Entering the era of nanoscience: time to be so small.Journal of biomedical nanotechnology · 2013Review
- Protein-mediated enamel mineralization.Frontiers in bioscience (Landmark edition) · 2012Review
- Effect of phosphorylation on the interaction of calcium with leucine-rich amelogenin peptide.European journal of oral sciences · 2011Article
- Hydrolysis of amelogenin by matrix metalloprotease-20 accelerates mineralization in vitro.Archives of oral biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The nucleation processes involved in calcium phosphate formation in tooth enamel are not well understood but are believed to involve proteins in the extracellular matrix. The ability of one enamel protein, amelogenin, to promote the nucleation and growth of calcium phosphate was studied in an in vitro system involving metastable supersaturated solutions. It was found that recombinant amelogenin (rM179 and rp(H)M180) promoted the nucleation of calcium phosphate compared to solutions without protein. The amount of calcium phosphate increased with increasing supersaturation of the solutions and increasing protein concentrations up to 6.5 μg/mL. At higher protein concentrations, the amount of calcium phosphate decreased. The kinetics of nucleation was studied in situ and in real time using a quartz crystal microbalance (QCM) and showed that the protein reduced the induction time for nucleation compared to solutions without protein. This work shows a nucleation role for amelogenin in vitro which may be promoted by the association of amelogenin into nanosphere templates, exposing charged functionality at the surface.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.