ReviewNature reviews. Microbiology2009
Doomsday postponed? Preventing and reversing epidemics of drug-resistant tuberculosis.
Review in Nature reviews. Microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 172 citations in OpenAlex.
- Incidence and Geographic Distribution of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa.PloS one · 2015Trial
- An Update to Novel Therapeutic Options for Combating Tuberculosis: Challenges and Future Prospectives.Current pharmaceutical biotechnology · 2024Review
- Integrity of the Actin Cytoskeleton of Host Macrophages is Necessary for Mycobacterial Entry.The Journal of membrane biology · 2022Review
- Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis.Nature medicine · 2021Article
- Spontaneous Selection ofAntimicrobial agents and chemotherapy · 2021Article
- Metabolic Changes ofPathogens (Basel, Switzerland) · 2020Article
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- Article
- Models of immune selection for multi-locus antigenic diversity of pathogens.Nature reviews. Immunology · 2019Review
- Tuberculosis outbreak investigation using phylodynamic analysis.Epidemics · 2018Article
- The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy.Genome biology · 2017Article
- Molecular detection of multidrug-resistant tuberculosis among smear-positive pulmonary tuberculosis patients in Jigjiga town, Ethiopia.Infection and drug resistance · 2017Article
- Host Antimicrobial Peptides: The Promise of New Treatment Strategies against Tuberculosis.Frontiers in immunology · 2017Review
- Extracts of six Rubiaceae species combined with rifampicin have good in vitro synergistic antimycobacterial activity and good anti-inflammatory and antioxidant activities.BMC complementary and alternative medicine · 2016Article
- Legionella pneumophila Carbonic Anhydrases: Underexplored Antibacterial Drug Targets.Pathogens (Basel, Switzerland) · 2016Review
- Genetic features of Mycobacterium tuberculosis modern Beijing sublineage.Emerging microbes & infections · 2016Article
- Pathways to multidrug-resistant tuberculosis diagnosis and treatment initiation: a qualitative comparison of patients' experiences in the era of rapid molecular diagnostic tests.BMC health services research · 2015Article
- The yield of screening symptomatic contacts of multidrug-resistant tuberculosis cases at a tertiary hospital in Addis Ababa, Ethiopia.BMC research notes · 2015Article
- Evolutionary consequences of drug resistance: shared principles across diverse targets and organisms.Nature reviews. Genetics · 2015Review
- Tuberculosis vaccine types and timings.Clinical and vaccine immunology : CVI · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis, now known to be present in 50 countries, heighten the threat posed by untreatable and fatal human tuberculosis (TB). To combat epidemics of drug-resistant TB, it is vital to understand why some resistant strains have greater reproductive fitness--a greater propensity to spread--than drug-susceptible strains. If public health malpractice has been a more important determinant of reproductive success than genetic mechanisms, then improved diagnosis and treatment could keep the frequency of resistant strains among TB cases low in any population. Recent data suggest that national TB control programmes that use existing drugs efficiently can postpone and even reverse epidemics of multidrug-resistant TB, although the effect of such programmes on XDR strains remains largely unknown.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.