ArticleNature methods2009
Cost-effective strategies for completing the interactome.
Article in Nature methods, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed.
- Review
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- Subtractive genomics and drug repurposing strategies for targetingFrontiers in microbiology · 2025Article
- Expression of DDSR1 Long Non-Coding RNA and Genes Involved in the DNA Damage Response in Sperm with DNA Fragmentation.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Next-generation large-scale binary protein interaction network for Drosophila melanogaster.Nature communications · 2023Article
- Identification of a Novel Therapeutic Target against XDRMicroorganisms · 2021Article
- Transcriptome analysis of the effect of a novel human serine protease inhibitor SPINK13 on gene expression in MHCC97-H cells.Translational cancer research · 2021Article
- Microarray expression profile of mRNAs and long noncoding RNAs and the potential role of PFK-1 in infantile hemangioma.Cell division · 2021Article
- Structural and Functional Elucidation of IF-3 Protein ofBioMed research international · 2021Article
- Comparative Metabolic Pathways Analysis and Subtractive Genomics Profiling to Prioritize Potential Drug Targets AgainstFrontiers in microbiology · 2021Article
- Article
- Immunomodulatory and Antioxidative potentials of adipose-derived Mesenchymal stem cells isolated from breast versus abdominal tissue: a comparative study.Cell regeneration (London, England) · 2020Article
- Article
- Protein-Protein Interactions Efficiently Modeled by Residue Cluster Classes.International journal of molecular sciences · 2020Article
- Genome-wide inference of the Camponotus floridanus protein-protein interaction network using homologous mapping and interacting domain profile pairs.Scientific reports · 2020Article
- Integrated analysis of long noncoding RNA and mRNA expression profile in children with obesity by microarray analysis.Scientific reports · 2018Article
- Article
- In silico cancer research towards 3R.BMC cancer · 2018Review
- Comprehensive genomic analysis of the CNGC gene family in Brassica oleracea: novel insights into synteny, structures, and transcript profiles.BMC genomics · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Comprehensive protein-interaction mapping projects are underway for many model species and humans. A key step in these projects is estimating the time, cost and personnel required for obtaining an accurate and complete map. Here we modeled the cost of interaction-map completion for various experimental designs. We showed that current efforts may require up to 20 independent tests covering each protein pair to approach completion. We explored designs for reducing this cost substantially, including prioritization of protein pairs, probability thresholding and interaction prediction. The best experimental designs lowered cost by fourfold overall and >100-fold in early stages of mapping. We demonstrate the best strategy in an ongoing project in Drosophila melanogaster, in which we mapped 450 high-confidence interactions using 47 microtiter plates, versus thousands of plates expected using current designs. This study provides a framework for assessing the feasibility of interaction mapping projects and for future efforts to increase their efficiency.
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Registered trials
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