Evidence map›Paper›PMID 19079212›Full record

ReviewMucosal immunology2008

Dendritic cells and macrophages in the genitourinary tract.

N Iijima, J M Thompson, A Iwasaki

Abstract readReview
In one paragraph

Review in Mucosal immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Langerhans cells: Central players in the pathophysiology of atopic dermatitis.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Vaginal delivery of vaccines.Advanced drug delivery reviews · 2021
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

N IijimaDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
J M Thompson
A Iwasaki

Funding

INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4M
Immunity to Genital Herpes Simplex-2R01AI054359 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2004 to 2019
$5.2M
Molecular and Cellular Transport in MucusR01EB000487 · NIBIB · YALE UNIVERSITY · PI IWASAKI, AKIKO, SALTZMAN, W. MARK · 2002 to 2019
$5.0M
Viral Recognition by plasmacytoid dendritic cellR01AI064705 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2006 to 2015
$3.9M
Antiviral CTL mobilization to the genital mucosaR01AI062428 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2005 to 2015
$3.9M
Antiviral CTL mobilization to the genital mucosaR56AI062428 · NIAID · YALE UNIVERSITY · PI IWASAKI, AKIKO · 2010 to 2010
$403k
NIAID NIH HHS AI054359NIAID NIH HHS AI 062428NIAID NIH HHS AI064705NIAID NIH HHS R01 AI054359NIAID NIH HHS R01 AI062428NIAID NIH HHS R01 AI064705NIAID NIH HHS R56 AI062428NIAID NIH HHS T32 AI007019NIAID NIH HHS T32 AI07019NIBIB NIH HHS R01 EB000487
6 · The paper itself

Abstract

Dendritic cells (DCs) and macrophages are antigen-presenting cells (APCs) that are important in innate immune defense as well as in the generation and regulation of adaptive immunity against a wide array of pathogens. The genitourinary (GU) tract, which serves an important reproductive function, is constantly exposed to numerous agents of sexually transmitted infections (STIs). To combat these STIs, several subsets of DCs and macrophages are strategically localized within the GU tract. In the female genital mucosa, recruitment and function of these APCs are uniquely governed by sex hormones. This review summarizes the latest advances in our understanding of DCs and macrophages in the GU tract with respect to their subsets, lineage, and function. In addition, we discuss the divergent roles of these cells in immune defense against STIs as well as in maternal tolerance to the fetus.

Indexed as

AnimalsDendritic CellsGonadal Steroid HormonesHumansImmune ToleranceMacrophagesSexually Transmitted DiseasesUrogenital SystemGonadal Steroid Hormones

Identifiers

PMID19079212
PMCPMC2684461

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.