ArticleMucosal immunology2008
Brokering the peace: the origin of intestinal T cells.
Article in Mucosal immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Intestinal T cells in aging: implications for gut barrier integrity and inflammaging.GeroScience · 2026Review
- Intraepithelial Lymphocytes of the Intestine.Annual review of immunology · 2024Review
- Rarity: discovering rare cell populations from single-cell imaging data.Bioinformatics (Oxford, England) · 2023Article
- γδ T Cells in Brain Homeostasis and Diseases.Frontiers in immunology · 2022Review
- Three Layers of Intestinal γδ T Cells Talk Different Languages With the Microbiota.Frontiers in immunology · 2022Review
- γδ T cell migration: Separating trafficking from surveillance behaviors at barrier surfaces.Immunological reviews · 2020Review
- T lymphocytes in the intestinal mucosa: defense and tolerance.Cellular & molecular immunology · 2019Review
- γδ T Cell-Mediated Immunity to Cytomegalovirus Infection.Frontiers in immunology · 2017Review
- Loss of Intra-Epithelial Endocervical Gamma Delta (GD) 1 T Cells in HIV-Infected Women.American journal of reproductive immunology (New York, N.Y. : 1989) · 2016Article
- Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance.Nature communications · 2015Article
- Regional specialization within the intestinal immune system.Nature reviews. Immunology · 2014Review
- FOXN1: A Master Regulator Gene of Thymic Epithelial Development Program.Frontiers in immunology · 2013Article
- Defining the nature of human γδ T cells: a biographical sketch of the highly empathetic.Cellular & molecular immunology · 2013Review
- Death diverted, but to what?Nature immunology · 2012Article
- The role of Peyer's patches in synchronizing gut IgA responses.Frontiers in immunology · 2012Article
- Selection of self-reactive T cells in the thymus.Annual review of immunology · 2012Review
- The light and dark sides of intestinal intraepithelial lymphocytes.Nature reviews. Immunology · 2011Review
- Intrinsic requirement for the vitamin D receptor in the development of CD8αα-expressing T cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In designating the thymic origin of the cells, the T in T cell seems simple enough, and the impressive unfolding of how the differentiation and selection of conventional CD4 and CD8 T cells are supported by the uniquely capable thymic stroma seems prima facie to leave little left to uncover. But, as the initial uncovering of T-cell receptor (TCR) gamma-chain genes forewarned, there are myriad "unconventional T cell" subtypes whose development is not easily explained by current understanding. Such cells, either TCR alphabeta(+) or TCR gamma delta(+), rarely express either CD4 (a coreceptor for major histocompatibility complex (MHC) II) or CD8 alphabeta (a coreceptor for MHC I).(2) Instead, they are CD4, CD8 double-negative (DN) or express a homomeric CD8 alpha alpha molecule. However, rather than being mere fringe players, worthy only of "page 2, column 3,"(3) these unconventional T cells compose a substantial fraction of perhaps the most abundant and most active T cells in the body--the intraepithelial lymphocytes (IELs)--that populate several body surfaces, including the gut. There, they seemingly contribute to the physiologic homeostasis that embraces epithelial integrity, the measured immune response to commensals, and the adaptive tolerance toward self-antigens. When this homeostasis is disrupted, IELs may also contribute to inflammatory and wound-healing responses. Given this, a strong interest in their origin is appropriate.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.