ArticleEMBO reports2009
Cellular senescence and organismal ageing in the absence of p21(CIP1/WAF1) in ku80(-/-) mice.
Article in EMBO reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Constitutive, Muscle-SpecificBiomedicines · 2024Article
- SATB2-Nanog axis links age-related intrinsic changes of mesenchymal stem cells from craniofacial bone.Aging · 2016Article
- Bax-induced apoptosis shortens the life span of DNA repair defect Ku70-knockout mice by inducing emphysema.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases.Cell death & disease · 2015Article
- Article
- REGγ deficiency promotes premature aging via the casein kinase 1 pathway.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence.International journal of molecular sciences · 2013Article
- Loss of a single allele for Ku80 leads to progenitor dysfunction and accelerated aging in skeletal muscle.EMBO molecular medicine · 2012Article
- The impact of cellular senescence in cancer therapy: is it true or not?Acta pharmacologica Sinica · 2011Review
- Article
- Examination of the expanding pathways for the regulation of p21 expression and activity.Cellular signalling · 2010Review
- Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3.Cellular and molecular life sciences : CMLS · 2010Article
- Effects of p21 deletion in mouse models of premature aging.Cell cycle (Georgetown, Tex.) · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Ku80 is important in the repair of DNA double-strand breaks by its essential function in non-homologous end-joining. The absence of Ku80 causes the accumulation of DNA damage and leads to premature ageing in mice. We showed that mouse embryonic fibroblasts (MEFs) from ku80(-/-) mice senesced rapidly with elevated levels of p53 and p21. Deletion of p21 delayed the early senescence phenotype in ku80(-/-) MEFs, despite an otherwise intact response of p53. In contrast to ku80(-/-)p53(-/-) mice, which die rapidly primarily from lymphomas, there was no significant increase in tumorigenesis in ku80(-/-)p21(-/-) mice. However, ku80(-/-)p21(-/-) mice showed no improvement with respect to rough fur coat or osteopaenia, and even showed a shortened lifespan compared with ku80(-/-) mice. These results show that the increased lifespan of ku80(-/-) MEFs owing to the loss of p21 is not associated with an improvement of the premature ageing phenotypes of ku80(-/-) mice observed at the organismal level.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.