ArticleThe EMBO journal2009
Circadian gene expression is resilient to large fluctuations in overall transcription rates.
Article in The EMBO journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
69 citing papers in PubMed, 143 citations in OpenAlex.
- A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Circadian Control of Protein Synthesis.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Transcription factor dynamics, oscillation, and functions in human enteroendocrine cell differentiation.Cell stem cell · 2024Article
- Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability.PLoS biology · 2023Article
- Phosphorylation of RNA Polymerase II by CDKC;2 Maintains the Arabidopsis Circadian Clock Period.Plant & cell physiology · 2022Article
- Core clock regulators in dexamethasone-treated HEK 293T cells at 4 h intervals.BMC research notes · 2022Article
- CRYPTOCHROMES promote daily protein homeostasis.The EMBO journal · 2022Article
- Autokinase Activity of Casein Kinase 1 δ/ε Governs the Period of Mammalian Circadian Rhythms.Journal of biological rhythms · 2019Article
- An Inactivation Switch Enables Rhythms in aInternational journal of molecular sciences · 2019Article
- Casein Kinase 1 Underlies Temperature Compensation of Circadian Rhythms in Human Red Blood Cells.Journal of biological rhythms · 2019Article
- Non-sinusoidal Waveform in Temperature-Compensated Circadian Oscillations.Biophysical journal · 2019Article
- New Insights Into the Circadian Rhythm and Its Related Diseases.Frontiers in physiology · 2019Article
- Deciphering the Dynamics of Interlocked Feedback Loops in a Model of the Mammalian Circadian Clock.Biophysical journal · 2018Article
- Non-transcriptional processes in circadian rhythm generation.Current opinion in physiology · 2018Review
- Design Principles of Phosphorylation-Dependent Timekeeping in Eukaryotic Circadian Clocks.Cold Spring Harbor perspectives in biology · 2018Review
- Circadian Posttranscriptional Regulatory Mechanisms in Mammals.Cold Spring Harbor perspectives in biology · 2018Review
- Seasonal loss and resumption of circadian rhythms in hibernating arctic ground squirrels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Temperature-amplitude coupling for stable biological rhythms at different temperatures.PLoS computational biology · 2017Article
- Timing the day: what makes bacterial clocks tick?Nature reviews. Microbiology · 2017Review
- Regulation of Mammalian Physiology by Interconnected Circadian and Feeding Rhythms.Frontiers in endocrinology · 2017Review
9 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian circadian oscillators are considered to rely on transcription/translation feedback loops in clock gene expression. The major and essential loop involves the autorepression of cryptochrome (Cry1, Cry2) and period (Per1, Per2) genes. The rhythm-generating circuitry is functional in most cell types, including cultured fibroblasts. Using this system, we show that significant reduction in RNA polymerase II-dependent transcription did not abolish circadian oscillations, but surprisingly accelerated them. A similar period shortening was observed at reduced incubation temperatures in wild-type mouse fibroblasts, but not in cells lacking Per1. Our data suggest that mammalian circadian oscillators are resilient to large fluctuations in general transcription rates and temperature, and that PER1 has an important function in transcription and temperature compensation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.