ArticleJournal of visualized experiments : JoVE2008
Preparation and maintenance of dorsal root ganglia neurons in compartmented cultures.
Article in Journal of visualized experiments : JoVE, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Compartmentalized Neuronal Culture for Viral Transport Research.Frontiers in microbiology · 2020Review
- Gabapentin prevents synaptogenesis between sensory and spinal cord neurons induced by thrombospondin-4 acting on pre-synaptic CaBritish journal of pharmacology · 2018Article
- Rabies Internalizes into Primary Peripheral Neurons via Clathrin Coated Pits and Requires Fusion at the Cell Body.PLoS pathogens · 2016Article
- The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability.Nature neuroscience · 2016Article
- Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons.Cell reports · 2015Article
- Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury.Neurobiology of disease · 2015Article
- Local protein synthesis in neuronal axons: why and how we study.BMB reports · 2015Review
- The kinesin-2 family member KIF3C regulates microtubule dynamics and is required for axon growth and regeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Corneal neurotoxicity due to topical benzalkonium chloride.Investigative ophthalmology & visual science · 2012Article
- Cyclosporine immunomodulation retards regeneration of surgically transected corneal nerves.Investigative ophthalmology & visual science · 2012Article
- Rab11 and its effector Rab coupling protein contribute to the trafficking of beta 1 integrins during axon growth in adult dorsal root ganglion neurons and PC12 cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Production of compartmented cultures of rat sympathetic neurons.Nature protocols · 2009Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Neurons extend axonal processes that are far removed from the cell body to innervate target tissues, where target-derived growth factors are required for neuronal survival and function. Neurotrophins are specifically required to maintain the survival and differentiation of innervating sensory neurons but the question of how these target-derived neurotrophins communicate to the cell body of innervating neurons has been an area of active research for over 30 years. The most commonly accepted model of how neurotrophin signals reach the cell body proposes that signaling endosomes carry this signal retrogradely along the axon. In order to study retrograde transport, a culture system was originally devised by Robert Campenot, in which cell bodies are isolated from their axons. The technique of preparing these compartmented chambers for culturing sensory neurons recapitulates the selective stimulation of neuron terminals that occurs in vivo following release of target-derived neurotrophins. Retrograde signaling events that require long-range microtubule dependent retrograde transport have important implications for the treatment of neurodegenerative disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.