ReviewCurrent opinion in pulmonary medicine2009
Rhinosinusitis and asthma: the missing link.
Review in Current opinion in pulmonary medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- 131 genetic loci highlight immunological pathways and tissues in nasal polyposis and asthma.Nature communications · 2025Pooled it
- The GSDMB rs7216389 SNP is associated with chronic rhinosinusitis in a multi-institutional cohort.International forum of allergy & rhinology · 2021Pooled it
- Guideline
- Exploring the Relationship between Wind Patterns and Hospital Admissions Due to Respiratory Symptoms in Children.Children (Basel, Switzerland) · 2024Article
- Exosomes Derived hsa-miR-4669 as a Novel Biomarker for Early Predicting the Response of Subcutaneous Immunotherapy in Pediatric Allergic Rhinitis.Journal of inflammation research · 2022Article
- A prospective pilot study on the effects of endoscopic sinus surgery on upper and lower airway performance.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2021Article
- Precision Medicine for Paediatric Severe Asthma: Current Status and Future Direction.Journal of asthma and allergy · 2021Review
- CFD Guided Optimization of Nose-to-Lung Aerosol Delivery in Adults: Effects of Inhalation Waveforms and Synchronized Aerosol Delivery.Pharmaceutical research · 2020Article
- Development of an Inline Dry Powder Inhaler for Oral or Trans-Nasal Aerosol Administration to Children.Journal of aerosol medicine and pulmonary drug delivery · 2020Article
- Asthma in the Primary Care Setting.The Medical clinics of North America · 2019Review
- Acute and chronic rhinosinusitis and allergic rhinitis in relation to comorbidity, ethnicity and environment.PloS one · 2018Article
- The characteristic of asthma control among nasal diseases population: Results from a cross-sectional study.PloS one · 2018Article
- Comparison of Oral Montelukast and Intranasal Fluticasone in Patients with Asthma and Allergic Rhinitis.Journal of clinical and diagnostic research : JCDR · 2016Article
- Article
- Asthma control among adults in Saudi Arabia. Study of determinants.Saudi medical journal · 2015Article
- Association of adenotonsillectomy with asthma outcomes in children: a longitudinal database analysis.PLoS medicine · 2014Article
- One airway: Biomarkers of protection from upper and lower airway injury after World Trade Center exposure.Respiratory medicine · 2014Article
- Differences in airway inflammation according to atopic status in patients with chronic rhinitis.Asia Pacific allergy · 2012Article
- Recent developments in United airways disease.Allergy, asthma & immunology research · 2012Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewDisease of the nose and sinuses is the most common comorbidity associated with asthma. Rhinitis, sinusitis and asthma may represent part of one disease process with manifestations at different sites. The purpose of this review is to highlight significant new findings on the epidemiological and pathophysiological link between the upper and lower airway. Finally, we will review recent data assessing the impact of treating sinonasal disease on both the development of asthma and asthma control. RECENT
findingsStudies illustrate that rhinitis is very common in asthma, and associated with worse asthma control. Rhinitis typically precedes the development of asthma. Even in patients with rhinitis without asthma, there is evidence of subclinical change in the lower airways as measured by physiological changes and the presence of inflammatory mediators. There is much interest on the impact of treating allergic rhinitis on the development of asthma. SUMMARY: Rhinitis, sinusitis and asthma are likely part of one disease process. Treatment of established rhinitis may have some impact on measures of airway obstruction, but an effect on lower airway inflammation is yet to be established. Prospective studies are required to determine whether treatment of rhinitis can prevent the development of asthma, or decrease airway inflammation to improve asthma outcomes in those with established asthma or both.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.