ArticleMalaria journal2008
A Plasmodium yoelii soluble factor inhibits the phenotypic maturation of dendritic cells.
Article in Malaria journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- The case for exploring innate memory in Plasmodium infection.Current opinion in microbiology · 2026Review
- Plasmodium yoelii as a model for malaria: insights into pathogenesis, drug resistance, and vaccine development.Molecular biology reports · 2025Review
- Dendritic Cells and Their Multiple Roles during Malaria Infection.Journal of immunology research · 2016Review
- One Episode of Self-Resolving Plasmodium yoelii Infection Transiently Exacerbates Chronic Mycobacterium tuberculosis Infection.Frontiers in microbiology · 2016Article
- Plasmodium falciparum induces Foxp3hi CD4 T cells independent of surface PfEMP1 expression via small soluble parasite components.Frontiers in microbiology · 2014Article
- Immune activation and regulation in simian immunodeficiency virus-Plasmodium fragile-coinfected rhesus macaques.Journal of virology · 2013Article
- Infection and treatment immunizations for successful parasite vaccines.Trends in parasitology · 2013Article
- Plasmodium falciparum-derived uric acid precipitates induce maturation of dendritic cells.PloS one · 2013Article
- Cytokine dysregulation associated with malarial anemia in Plasmodium yoelii infected mice.American journal of translational research · 2013Article
- Hostile takeover by Plasmodium: reorganization of parasite and host cell membranes during liver stage egress.PLoS pathogens · 2011Article
- Dual effect of Plasmodium-infected erythrocytes on dendritic cell maturation.Malaria journal · 2010Article
- Modulation of dendritic cell responses by parasites: a common strategy to survive.Journal of biomedicine & biotechnology · 2010Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundInfection with the protozoan parasite Plasmodium is the cause of malaria. Plasmodium infects host erythrocytes causing the pathology of the disease. Plasmodium-infected erythrocytes can modulate the maturation of dendritic cells (DCs) and alter their capacity to activate T cells.
methodsMice infected with Plasmodium yoelii and isolated P. yoelii-infected erythrocytes were used to study their effect on the maturation of mouse dendritic cells.
resultsDCs are not able to mature in response to LPS injection during the late stage of P. yoelii infection in mice, indicating impaired functionality of these cells in vivo. P. yoelii- infected erythrocytes inhibit the maturation of DCs in vitro in a dose-dependent manner, which is consistent with the inhibition found during late infection when parasite burden is highest. The inhibition of DC maturation and the cytokine secretion profile of DCs are modulated by soluble factors released by P. yoelii-infected erythrocytes. A small, heat-stable, non-hydrophobic molecule of P. yoelii-infected erythrocytes rapidly inhibits the LPS induced phenotypic maturation of DCs in a reversible manner.
conclusionThese findings add evidence to the malaria associated immune suppression in vivo and in vitro and provide insight into the nature and mechanism of the Plasmodium factor(s) responsible for altering DC functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.