ArticleMalaria journal2008
Opposed circulating plasma levels of endothelin-1 and C-type natriuretic peptide in children with Plasmodium falciparum malaria.
Article in Malaria journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Decreased level of serum NT-proCNP associates with disease severity in COVID-19.Respiratory research · 2023Article
- Article
- Cerebral Malaria: Current Clinical and Immunological Aspects.Frontiers in immunology · 2022Review
- Bartonella henselae infection induces a persistent mechanical hypersensitivity in mice.Revista do Instituto de Medicina Tropical de Sao Paulo · 2020Article
- Endothelins in inflammatory neurological diseases.Pharmacology & therapeutics · 2019Review
- Brain Endothelium: The "Innate Immunity Response Hypothesis" in Cerebral Malaria Pathogenesis.Frontiers in immunology · 2018Review
- Endothelin-1 Treatment Induces an Experimental Cerebral Malaria-Like Syndrome in C57BL/6 Mice Infected with Plasmodium berghei NK65.The American journal of pathology · 2016Article
- Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria.PLoS pathogens · 2016Article
- The evidence for a role of vasospasm in the pathogenesis of cerebral malaria.Malaria journal · 2015Review
- Endothelin-1 and its role in the pathogenesis of infectious diseases.Life sciences · 2014Review
- Vascular dysfunction as a target for adjuvant therapy in cerebral malaria.Memorias do Instituto Oswaldo Cruz · 2014Review
- Clinical relevance of different biomarkers in imported plasmodium falciparum malaria in adults: a case control study.Malaria journal · 2013Article
- Comparative measurement of CNP and NT-proCNP in human blood samples: a methodological evaluation.Journal of negative results in biomedicine · 2013Article
- Nitric oxide synthase dysfunction contributes to impaired cerebroarteriolar reactivity in experimental cerebral malaria.PLoS pathogens · 2013Article
- Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology.The Journal of infectious diseases · 2011Article
- Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine.The American journal of pathology · 2010Article
- Medical research at the Albert Schweitzer Hospital.Wiener klinische Wochenschrift · 2010Article
- The lipid moiety of haemozoin (Malaria Pigment) and P. falciparum parasitised red blood cells bind synthetic and native endothelin-1.Journal of biomedicine & biotechnology · 2010Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMolecular mechanisms involved in the pathogenesis of severe Plasmodium falciparum malaria (SM), are not yet fully understood. Both endothelin-1 (ET-1) and C-type natriuretic peptide (CNP) are produced by vascular endothelium and act locally as paracrine regulators of vascular tone, ET-1 being a potent vasoconstrictor and CNP having strong vasorelaxant properties.
methodsPlasma levels of ET-1 and N-terminal fragments of CNP (NT-proCNP) were studied on admission and after 24 hours of treatment, using enzyme-linked-immunosorbent-assay (ELISA) technique, in Gabonese children with severe falciparum malaria (SM, n = 50), with uncomplicated malaria (UM, n = 39) and healthy controls (HC, n = 25).
resultsCompared to HC, malaria patients had significantly higher plasma levels of ET-1 and significantly lower levels of NT-proCNP (p < 0.001 and p < 0.024 respectively). Plasma levels of NT-proCNP were additionally decreased in SM patients compared to HC (p = 0.034), whereas UM was not significantly different to HC. In the SM group we found a trend towards lower ET-1 levels compared to UM (p = 0.085).
conclusionIn the present study, an imbalance between the vasoconstricitve and vasorelaxant endothelium-derived substances ET-1 and CNP in the plasma of children with falciparum malaria is demonstrated, presumably in favor of vasoconstrictive and pro-inflammatory effects. These results may indicate involvement of ET-1 and CNP in malaria pathogenesis. Furthermore, results of lower ET-1 and CNP levels in SM may reflect endothelial cell damage.
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