ArticleBMC gastroenterology2008
Alcohol consumption is associated with an increased risk of erosive esophagitis and Barrett's epithelium in Japanese men.
Article in BMC gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Alcohol consumption and the risk of Barrett's esophagus: a comprehensive meta-analysis.Scientific reports · 2015Pooled it
- Prevalence of Barrett's Esophagus in Asian Countries: A Systematic Review and Meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Pooled it
- Association Between Alcohol Consumption and the Risk of Barrett's Esophagus: A Meta-Analysis of Observational Studies.Medicine · 2015Pooled it
- Increased Prevalence of Barrett's Esophagus in Taiwan: A Prospective Multicenter Study.Journal of gastroenterology and hepatology · 2025Article
- Marijuana Use as a Lifestyle Factor Associated With Gastroesophageal Reflux Disease (GERD) Complications.American journal of lifestyle medicine · 2025Article
- Inverse relations betweenWorld journal of gastrointestinal oncology · 2022Article
- Spectrum of esophageal motility disorders in patients with liver cirrhosis.World journal of hepatology · 2020Review
- Risk Prediction Models for Barrett's Esophagus Discriminate Well and Are Generalizable in an External Validation Study.Digestive diseases and sciences · 2020Article
- Krt5Nature communications · 2019Article
- Astragaloside IV Protects Ethanol-Induced Gastric Mucosal Injury by Preventing Mitochondrial Oxidative Stress and the Activation of Mitochondrial Pathway Apoptosis in Rats.Frontiers in pharmacology · 2019Article
- Influence of hiatal hernia and male sex on the relationship between alcohol intake and occurrence of Barrett's esophagus.PloS one · 2018Article
- Alcohol accumulation promotes esophagitis via pyroptosis activation.International journal of biological sciences · 2018Article
- Presence of columnar-lined esophagus is negatively associated with the presence of esophageal varices in Japanese alcoholic men.World journal of gastroenterology · 2017Observational
- Clinical Characteristics of Severe Erosive Esophagitis among Patients with Erosive Esophagitis: A Case-control Study.Internal medicine (Tokyo, Japan) · 2017Article
- Alcohol consumption and corresponding factors: A novel perspective on the risk factors of esophageal cancer.Oncology letters · 2016Article
- Association of Visceral Fat Area, Smoking, and Alcohol Consumption with Reflux Esophagitis and Barrett's Esophagus in Japan.PloS one · 2015Article
- Alcoholic disease: liver and beyond.World journal of gastroenterology · 2014Review
- Barrett esophagus in Asia: same disease with different pattern.Clinical endoscopy · 2014Review
- Population-based assessment of heartburn in urban Black Americans.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2013Article
- Overweight associated with increased risk of erosive esophagitis in a non-obese Taiwanese population.PloS one · 2013Article
Corrections and comments
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Authors and funding
16 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEvidence regarding the association between alcohol consumption and the gastro-esophageal reflux disease (GERD) spectrum has been conflicting. We examined the association between alcohol consumption and erosive esophagitis and Barrett's epithelium in Japanese men.
methodsThe study population comprised 463 men subjects who had undergone an upper endoscopy at the Gastroenterology Division of Yokohama City University Hospital between August 2005 and July 2006. The presence of erosive esophagitis and Barrett's epithelium was diagnosed based on the Los Angeles Classification and the Prague C and M Criteria, respectively. We divided the study population into four groups: never drinkers, light drinkers (less than 25.0 g of ethanol per day), moderate drinkers (25.0 to 50.0 g of ethanol per day), and heavy drinkers (more than 50.0 g of ethanol per day). A linear regression of the logistic regression analysis was used to analyze the dose-response trends.
resultsCompared with never drinkers, light drinkers (less than 25.0 g ethanol per day), moderate drinkers (25.0 to 50.0 g per day), and heavy drinkers (more than 50.0 g per day) had ORs for erosive esophagitis of 1.110 (95% CI: 0.553 - 2.228, p = 0.7688), 1.880 (95% CI: 1.015 - 3.484, p = 0.0445) and 1.988 (95% CI: 1.120 - 3.534, p = 0.0190), respectively. These groups had ORs for Barrett's epithelium of 1.278 (95% CI: 0.752 - 2.170, p = 0.3643), 1.458 (95% CI: 0.873 - 2.433, p = 0.1500), and 1.912 (95% CI: 1.185 - 3.086, p = 0.0079), respectively. The odds ratios/grams (alcohol)/day of dose response trends for erosive esophagitis and Barrett's epithelium were 1.015 (95% CI: 1.004-1.026, p = 0.0066) and 1.012 (95% CI: 1.003-1.021, p = 0.0079), respectively.
conclusionThese findings suggest that alcohol consumption in Japanese men tends to be associated with an increased risk of erosive esophagitis and Barrett's epithelium.
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Registered trials
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