ArticleBMC microbiology2008
Intragenic tandem repeat variation between Legionella pneumophila strains.
Article in BMC microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Clinical characteristics and microbial signatures in the lower airways of diabetic and nondiabetic patients with pneumonia.Journal of thoracic disease · 2024Article
- The Legionella collagen-like protein employs a distinct binding mechanism for the recognition of host glycosaminoglycans.Nature communications · 2024Article
- Genome Sequencing Links Persistent Outbreak of Legionellosis in Sydney (New South Wales, Australia) to an Emerging Clone of Legionella pneumophila Sequence Type 211.Applied and environmental microbiology · 2018Article
- Cyclic AMP-Independent Control of Twitching Motility in Pseudomonas aeruginosa.Journal of bacteriology · 2017Article
- Temperature-Dependent Growth Modeling of Environmental and Clinical Legionella pneumophila Multilocus Variable-Number Tandem-Repeat Analysis (MLVA) Genotypes.Applied and environmental microbiology · 2017Article
- The Conserved Tetratricopeptide Repeat-Containing C-Terminal Domain of Pseudomonas aeruginosa FimV Is Required for Its Cyclic AMP-Dependent and -Independent Functions.Journal of bacteriology · 2016Article
- Comparative genome analysis of Weissella ceti, an emerging pathogen of farm-raised rainbow trout.BMC genomics · 2015Article
- Hybrid de novo tandem repeat detection using short and long reads.BMC medical genomics · 2015Article
- Deep conservation of human protein tandem repeats within the eukaryotes.Molecular biology and evolution · 2014Article
- Host adaptation of Chlamydia pecorum towards low virulence evident in co-evolution of the ompA, incA, and ORF663 Loci.PloS one · 2014Article
- A pilot study of rapid whole-genome sequencing for the investigation of a Legionella outbreak.BMJ open · 2013Article
- Article
- Whole genome sequences of three Treponema pallidum ssp. pertenue strains: yaws and syphilis treponemes differ in less than 0.2% of the genome sequence.PLoS neglected tropical diseases · 2012Article
- The peptidoglycan-binding protein FimV promotes assembly of the Pseudomonas aeruginosa type IV pilus secretin.Journal of bacteriology · 2011Article
- Article
- Variable numbers of tandem repeats in Plasmodium falciparum genes.Journal of molecular evolution · 2010Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBacterial genomes harbour a large number of tandem repeats, yet the possible phenotypic effects of those found within the coding region of genes are only beginning to be examined. Evidence exists from other organisms that these repeats can be involved in the evolution of new genes, gene regulation, adaptation, resistance to environmental stresses, and avoidance of the immune system.
resultsIn this study, we have investigated the presence and variability in copy number of intragenic tandemly repeated sequences in the genome of Legionella pneumophila, the etiological agent of a severe pneumonia known as Legionnaires' disease. Within the genome of the Philadelphia strain, we have identified 26 intragenic tandem repeat sequences using conservative selection criteria. Of these, seven were "polymorphic" in terms of repeat copy number between a large number of L. pneumophila serogroup 1 strains. These strains were collected from a wide variety of environments and patients in several geographical regions. Within this panel of strains, all but one of these seven genes exhibited statistically different patterns in repeat copy number between samples from different origins (environmental, clinical, and hot springs).
conclusionThese results support the hypothesis that intragenic tandem repeats could play a role in virulence and adaptation to different environments. While tandem repeats are an increasingly popular focus of molecular typing studies in prokaryotes, including in L. pneumophila, this study is the first examining the difference in tandem repeat distribution as a function of clinical or environmental origin.
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