ArticleClinical and experimental immunology2009
Proinflammatory cytokine gene single nucleotide polymorphisms in common variable immunodeficiency.
Article in Clinical and experimental immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Association between polymorphism of interleukin-1 beta and interleukin-1 receptor antagonist gene and asthma risk: a meta-analysis.TheScientificWorldJournal · 2015Pooled it
- Severe conjunctival allergic reaction to polyglactin 910 sutures following strabismus surgery: A case report.International journal of surgery case reports · 2024Article
- Autoimmune Cytopenias in Common Variable Immunodeficiency Are a Diagnostic and Therapeutic Conundrum: An Update.Frontiers in immunology · 2022Review
- Variable immunodeficiency score upfront analytical link (VISUAL), a proposal for combined prognostic score at diagnosis of common variable immunodeficiency.Scientific reports · 2021Article
- Primary Immunodeficiencies: Diseases of Children and Adults - A Review.Advances in experimental medicine and biology · 2021Review
- Trained Immunity Based-Vaccines as a Prophylactic Strategy in Common Variable Immunodeficiency. A Proof of Concept Study.Biomedicines · 2020Article
- Interleukin-10 and Transforming Growth Factor Beta1 Gene Polymorphisms in Chronic Heart Failure.Acta bio-medica : Atenei Parmensis · 2019Article
- Article
- The association between interleukin-4 -590C/T genetic polymorphism, IL-4 serum level, and advanced endometriosis.Central-European journal of immunology · 2016Article
- Hepatitis C virus core protein triggers expansion and activation of CD4(+)CD25(+) regulatory T cells in chronic hepatitis C patients.Cellular & molecular immunology · 2015Article
- Lack of association between interleukin-10, transforming growth factor-beta gene polymorphisms and juvenile-onset systemic lupus erythematosus.Clinical rheumatology · 2015Article
- Significance of IL-1RA Polymorphism in Iranian Patients with Inflammatory Bowel Disease.Digestive diseases and sciences · 2015Article
- Cytokines in common variable immunodeficiency as signs of immune dysregulation and potential therapeutic targets - a review of the current knowledge.Journal of clinical immunology · 2014Review
- T-helper 1, T-helper 2, and T-regulatory cytokines gene polymorphisms in irritable bowel syndrome.Inflammation · 2010Article
- History of primary immunodeficiency diseases in iran.Iranian journal of pediatrics · 2010Article
- Proinflammatory cytokine gene polymorphisms in irritable bowel syndrome.Journal of clinical immunology · 2010Article
- Mannose-binding lectin polymorphisms in common variable immunodeficiency.Clinical and experimental medicine · 2009Article
- IL-2, IFN-gamma, and IL-12 gene polymorphisms and susceptibility to multiple sclerosis.Journal of clinical immunology · 2009Article
- Genetics of hypogammaglobulinemia: what do we really know?Current opinion in immunology · 2009Review
- Autoimmunity in common variable immunodeficiency.Current allergy and asthma reports · 2009Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Common variable immunodeficiency (CVID) is a heterogeneous group of primary immunodeficiency diseases. Cytokine production could be affected in CVID patients, whereas its alteration could be due to genetic polymorphisms within coding and promoter regions of the cytokine genes. This study was performed to analyse the proinflammatory cytokine single nucleotide polymorphisms in CVID. The allele and genotype frequencies of a number polymorphic genes coding tumour necrosis factor (TNF)-alpha, interleukin (IL)-1alpha, IL-1beta, IL-1R, IL-1RA and IL-6 were investigated and compared between two groups of CVID patients and controls. The IL-6 GA genotype at position nt565 was significantly over-represented in the patient group (P<0.001), while the IL-6 GG genotype at position -174 (P=0.006) and the GG genotype at position nt565 (P<0.001) were significantly lower than controls. The TNF-alpha AG genotype at position -308 in the patient group was increased significantly in comparison with controls (P=0.027), but the GG genotype at the same position was significantly decreased (P=0.011). IL-6 CA and GA haplotypes were the most frequent haplotypes in the patients (P<0.005), whereas TNF-alpha GA (P=0.002) and IL-6 GG (P<0.001) haplotypes were decreased significantly in the patients in comparison with controls. Cytokine single nucleotide polymorphisms could have a role in pathophysiology of CVID. High production of TNF-alpha is expected in some CVID patients based on the frequency of genotypes/haplotypes of these cytokine gene polymorphisms.
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