Evidence map›Paper›PMID 19076824›Full record

ReviewClinical and experimental immunology2009

The role of infections in autoimmune disease.

A M Ercolini, S D Miller

Open access · greenAbstract readReview
In one paragraph

Review in Clinical and experimental immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 185 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
185citing papers in PubMed, 3 pooled it
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

185 citing papers in PubMed, 3 syntheses or guidelines pooled it, 415 citations in OpenAlex.

  1. Pooled it
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  18. Efferocytosis in Homeostasis.Advances in experimental medicine and biology · 2025
    Review
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125 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

A M ErcoliniDepartment of Microbiology-Immunology and Interdepartmental Immunobiology Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
S D Miller
Northwestern University · US

Funding

T-CELL IMMUNITY IN TMEV-INDUCED DEMYELINATIONP01NS023349 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIPTON, HOWARD LEE · 1986 to 2007
$8.9M
NINDS NIH HHS P01 NS023349
6 · The paper itself

Abstract

Autoimmunity occurs when the immune system recognizes and attacks host tissue. In addition to genetic factors, environmental triggers (in particular viruses, bacteria and other infectious pathogens) are thought to play a major role in the development of autoimmune diseases. In this review, we (i) describe the ways in which an infectious agent can initiate or exacerbate autoimmunity; (ii) discuss the evidence linking certain infectious agents to autoimmune diseases in humans; and (iii) describe the animal models used to study the link between infection and autoimmunity.

Indexed as

AnimalsAutoimmune DiseasesBacterial InfectionsDisease Models, AnimalHumansModels, AnimalParasitic DiseasesVirus Diseases

Identifiers

PMID19076824
PMCPMC2665673
OpenAlexW2101818249

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.