Evidence map›Paper›PMID 19076777›Full record

ArticleBrain pathology (Zurich, Switzerland)2009

Brain tumor susceptibility: the role of genetic factors and uses of mouse models to unravel risk.

Karlyne M Reilly

Open access · greenAbstract read
In one paragraph

Article in Brain pathology (Zurich, Switzerland), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 54 citations in OpenAlex.

  1. Antibody-conjugated polymer nanoparticles for brain cancer.Drug delivery and translational research · 2025
    Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Modeling Brain Tumors: A Perspective Overview ofFrontiers in molecular neuroscience · 2022
    Review
  7. Review
  8. Review
  9. Review
  10. Pre-clinical tumor models of primary brain tumors: Challenges and opportunities.Biochimica et biophysica acta. Reviews on cancer · 2021
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Automated gene expression pattern annotation in the mouse brain.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2015
    Article
  17. The potential effect of gender in CYP1A1 and GSTM1 genotype-specific associations with pediatric brain tumor.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2013
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Karlyne M ReillyMouse Cancer Genetics Program, National Cancer Institute-Frederick, Frederick, MD 21702, USA. kreilly@ncifcrf.gov
National Cancer Institute · US

Funding

Identification of Modifier Gene of Tumors Associated with NF1 and AstrocytomaZIABC010539 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI REILLY, KARLYNE M · 2009 to 2014
$4.1M
Identification of Modifier Gene of Tumors Associated with NF1 and AstrocytomaZ01BC010539 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI REILLY, KARLYNE · 2003 to 2008
$1.4M
Intramural NIH HHS Z01 BC010539Intramural NIH HHS Z99 CA999999
6 · The paper itself

Abstract

Brain tumors are relatively rare but deadly cancers, and present challenges in the determination of risk factors in the population. These tumors are inherently difficult to cure because of their protected location in the brain, with surgery, radiation and chemotherapy options carrying potentially lasting morbidity for patients and incomplete cure of the tumor. The development of methods to prevent or detect brain tumors at an early stage is extremely important to reduce damage to the brain from the tumor and the therapy. Developing effective prevention or early detection methods requires a deep understanding of the risk factors for brain tumors. This review explores the difficulties in assessing risk factors in rare diseases such as brain tumors, and discusses how mouse models of cancer can aid in a better understanding of genetic risk factors for brain tumors.

Indexed as

Disease Models, AnimalAnimalsAstrocytomaBrain NeoplasmsGenetic Predisposition to DiseaseHumansMiceMice, TransgenicRisk Factors

Identifiers

PMID19076777
PMCPMC2761018
OpenAlexW2115448148

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.