ReviewCurrent gene therapy2008
Applications of lentiviral vectors for shRNA delivery and transgenesis.
Review in Current gene therapy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed.
- Establishment of Nile Tilapia Primary Cell Culture Methods and In Vitro Cell Knockdown Techniques.Marine biotechnology (New York, N.Y.) · 2024Article
- Engineering lentivirus envelope VSV-G for liver targeted delivery of IDOL-shRNA to ameliorate hypercholesterolemia and atherosclerosis.Molecular therapy. Nucleic acids · 2024Article
- Therapeutic Potential of Combinative shRNA-Encoded Lentivirus-Mediated Gene Silencing to Accelerate Somatosensory Recovery After Spinal Cord Trauma.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Article
- Stable expression of shRNA for the control of recombinant adenovirus replication.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Article
- The role of gap junctions in cell death and neuromodulation in the retina.Neural regeneration research · 2021Review
- Treponema denticola dentilisin triggered TLR2/MyD88 activation upregulates a tissue destructive program involving MMPs via Sp1 in human oral cells.PLoS pathogens · 2021Article
- Article
- Intracellular distribution and internalization pathways of guanidinylated bioresponsive poly(amido amine)s in gene delivery.Asian journal of pharmaceutical sciences · 2018Article
- A novel experimental model for human mixed acinar-ductal pancreatic cancer.Carcinogenesis · 2018Article
- Article
- A streamlined method for the design and cloning of shRNAs into an optimized Dox-inducible lentiviral vector.BMC biotechnology · 2017Article
- Brain-Derived Neurotrophic Factor Knockdown Blocks the Angiogenic and Protective Effects of Angiotensin Modulation After Experimental Stroke.Molecular neurobiology · 2017Article
- MicroRNA-34a affects chondrocyte apoptosis and proliferation by targeting the SIRT1/p53 signaling pathway during the pathogenesis of osteoarthritis.International journal of molecular medicine · 2016Article
- The adaptor protein Disabled-2: new insights into platelet biology and integrin signaling.Thrombosis journal · 2016Review
- Quantitative evaluation of first, second, and third generation hairpin systems reveals the limit of mammalian vector-based RNAi.RNA biology · 2016Article
- Embryo development, fetal growth and postnatal phenotype of eGFP lambs generated by lentiviral transgenesis.Transgenic research · 2015Article
- Single and Multiple Gene Manipulations in Mouse Models of Human Cancer.Cancer growth and metastasis · 2015Review
- Viral bimolecular fluorescence complementation: a novel tool to study intracellular vesicular trafficking pathways.PloS one · 2015Article
- Targeting eradication of chronic myeloid leukemia using chimeric oncolytic adenovirus to drive IL-24 expression.International journal of clinical and experimental pathology · 2015Article
- Targeting the cell cycle inhibitor p57Kip2 promotes adult human β cell replication.The Journal of clinical investigation · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Lentiviral vectors are potent gene delivery vehicles that enable stable expression of transgenes in both dividing and post-mitotic cells. Development of lentiviral vectors expressing small hairpin RNAs generates a system that can be used to down regulate specific target genes in vivo and in vitro. In this review, we will discuss two examples of in vivo applications for the use of lentiviral vectors expressing shRNAs: Gene therapy of neurological disorders and generation of transgenic knockdown animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.