ArticleThe Journal of experimental medicine2008
Involvement of Artemis in nonhomologous end-joining during immunoglobulin class switch recombination.
Article in The Journal of experimental medicine, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Recombination junctions from antibody isotype switching classify immune and DNA repair dysfunction.Nature communications · 2025Article
- Orientation Regulation of Class-switch Recombination in Human B Cells.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination.eLife · 2022Article
- Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome.The Journal of experimental medicine · 2020Article
- Recent advances in the study of immunodeficiency and DNA damage response.International journal of hematology · 2017Review
- Programmed DNA breaks in lymphoid cells: repair mechanisms and consequences in human disease.Immunology · 2016Review
- DCLRE1C (ARTEMIS) mutations causing phenotypes ranging from atypical severe combined immunodeficiency to mere antibody deficiency.Human molecular genetics · 2015Article
- Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- IgA subclass switch recombination in human mucosal and systemic immune compartments.Mucosal immunology · 2014Article
- The cohesin complex regulates immunoglobulin class switch recombination.The Journal of experimental medicine · 2013Article
- A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination.The Journal of experimental medicine · 2013Article
- Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.Nature reviews. Immunology · 2012Review
- Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis.The Journal of experimental medicine · 2012Article
- Expressional analysis of immunoglobulin D in cattle (Bos taurus), a large domesticated ungulate.PloS one · 2012Article
- Artemis splice defects cause atypical SCID and can be restored in vitro by an antisense oligonucleotide.Genes and immunity · 2011Article
- Abnormalities in DNA double-strand break response beyond primary immunodeficiency.International journal of hematology · 2011Article
- Impaired induction of DNA lesions during immunoglobulin class-switch recombination in humans influences end-joining repair.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Downstream class switching leads to IgE antibody production by B lymphocytes lacking IgM switch regions.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA double-strand breaks (DSBs) introduced in the switch (S) regions are intermediates during immunoglobulin class switch recombination (CSR). These breaks are subsequently recognized, processed, and joined, leading to recombination of the two S regions. Nonhomologous end-joining (NHEJ) is believed to be the principle mechanism involved in DSB repair during CSR. One important component in NHEJ, Artemis, has however been considered to be dispensable for efficient CSR. In this study, we have characterized the S recombinational junctions from Artemis-deficient human B cells. Smu-Salpha junctions could be amplified from all patients tested and were characterized by a complete lack of "direct" end-joining and a remarkable shift in the use of an alternative, microhomology-based end-joining pathway. Smu-Sgamma junctions could only be amplified from one patient who carries "hypomorphic" mutations. Although these Smu-Sgamma junctions appear to be normal, a significant increase of an unusual type of sequential switching from immunoglobulin (Ig)M, through one IgG subclass, to a different IgG subclass was observed, and the Sgamma-Sgamma junctions showed long microhomologies. Thus, when the function of Artemis is impaired, varying modes of CSR junction resolution may be used for different S regions. Our findings strongly link Artemis to the predominant NHEJ pathway during CSR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.